Evidence map›Paper›PMID 38370680›Full record

ArticlebioRxiv : the preprint server for biology2024

A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules.

Moamen M Elmassry, Kohei Sugihara, Pranatchareeya Chankhamjon, Francine R Camacho, Shuo Wang, Yuki Sugimoto, Seema Chatterjee, Lea Ann Chen, Nobuhiko Kamada, Mohamed S Donia

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Moamen M ElmassryDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.
Kohei SugiharaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Pranatchareeya ChankhamjonDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.
Francine R CamachoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, 08544, USA.
Shuo WangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, 08544, USA.
Yuki SugimotoDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.
Seema ChatterjeeDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.
Lea Ann ChenDepartment of Medicine, Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, 08901, USA.
Nobuhiko KamadaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Mohamed S DoniaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.
Princeton University · USUniversity of Michigan · USRutgers, The State University of New Jersey · US

Funding

The role of IL-1ß-inducing pathobionts in the pathogenesis of Crohn’s diseaseR01DK108901 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nobuhiko Kamada · 2017 to 2026
$3.8M
Systematic characterization of bioactive molecules from the human microbiomeR01AI172144 · NIAID · PRINCETON UNIVERSITY · PI ABOU DONIA, MOHAMED · 2022 to 2025
$3.4M
Uncultivated bacterial symbionts of humans: an untapped resource for drug discoveryDP2AI124441 · NIAID · PRINCETON UNIVERSITY · PI ABOU DONIA, MOHAMED · 2015 to 2015
$2.4M
The Study of Families with Heritable Crohn's Disease to Support Rational Design of Microbiota-based TherapiesK23DK119544 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CHEN, LEA A · 2020 to 2024
$1.1M
NIAID NIH HHS DP2 AI124441NIAID NIH HHS R01 AI172144NIDDK NIH HHS K23 DK119544NIDDK NIH HHS R01 DK108901
6 · The paper itself

Abstract

Changes in the gut microbiome have been associated with several human diseases, but the molecular and functional details underlying these associations remain largely unknown. Here, we performed a multi-cohort analysis of small molecule biosynthetic gene clusters (BGCs) in 5,306 metagenomic samples of the gut microbiome from 2,033 Inflammatory Bowel Disease (IBD) patients and 833 matched healthy subjects and identified a group of Clostridia-derived BGCs that are significantly associated with IBD. Using synthetic biology, we discovered and solved the structures of six fatty acid amides as the products of the IBD-enriched BGCs. Using two mouse models of colitis, we show that the discovered small molecules disrupt gut permeability and exacerbate inflammation in chemically and genetically susceptible mice. These findings suggest that microbiome-derived small molecules may play a role in the etiology of IBD and represent a generalizable approach for discovering molecular mediators of microbiome-host interactions in the context of microbiome-associated diseases.

Identifiers

PMID38370680
PMCPMC10871352
OpenAlexW4391692019

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.