ArticlebioRxiv : the preprint server for biology2024
Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to
Jack Houston, Clémence Vissotsky, Amar Deep, Hiro Hakozaki, Enice Crews, Karen Oegema, Kevin D Corbett, Pablo Lara-Gonzalez, Taekyung Kim, Arshad Desai
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors at 3 institutions in 2 countries.
Jack HoustonBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, California 92093, USA.ORCID 0009-0009-6036-5101 Clémence VissotskyLudwig Institute for Cancer Research, La Jolla, California 92093, USA.
Amar DeepDepartment of Cellular & Molecular Medicine, University of California San Diego, La Jolla, California 92093, USA.
Hiro HakozakiDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0009-0008-2503-0480 Enice CrewsDepartment of Cell & Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA.
Karen OegemaBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, California 92093, USA.
Kevin D CorbettBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, California 92093, USA.
Pablo Lara-GonzalezLudwig Institute for Cancer Research, La Jolla, California 92093, USA.
Taekyung KimLudwig Institute for Cancer Research, La Jolla, California 92093, USA.
Arshad DesaiBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, California 92093, USA.
University of California San Diego · USLudwig Cancer Research · USUniversity of California, Irvine · US
Funding
Kinetochore Specification and FunctionR01GM074215 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DESAI, ARSHAD · 2005 to 2025
$8.2MAnalysis of Centrosome DynamicsR01GM074207 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OEGEMA, KAREN F · 2006 to 2025
$6.6MMolecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunityR35GM144121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett · 2022 to 2026
$2.7MDevelopmental regulation of the cell cycle machineryR35GM150786 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pablo Andres Lara-Gonzalez · 2023 to 2026
$1.5MAcquisition of an Orbitrap Elite with ETDS10OD021724 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 2016 to 2016
$600kNIGMS NIH HHS R01 GM074207NIGMS NIH HHS R01 GM074215NIGMS NIH HHS R35 GM144121NIGMS NIH HHS R35 GM150786NIH HHS S10 OD021724
6 · The paper itselfAbstract
During mitosis, the Bub1-Bub3 complex concentrates at kinetochores, the microtubule-coupling interfaces on chromosomes, where it contributes to spindle checkpoint activation, kinetochore-spindle microtubule interactions, and protection of centromeric cohesion. Bub1 has a conserved N-terminal tetratricopeptide (TPR) domain followed by a binding motif for its conserved interactor Bub3. The current model for Bub1-Bub3 localization to kinetochores is that Bub3, along with its bound motif from Bub1, recognizes phosphorylated "MELT" motifs in the kinetochore scaffold protein Knl1. Motivated by the greater phenotypic severity of BUB-1 versus BUB-3 loss in
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PMID38370671
PMCPMC10871365
OpenAlexW4391750640
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