Evidence map›Paper›PMID 38370670›Full record

ArticlebioRxiv : the preprint server for biology2024

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.

Bin Liu, Dan Yi, Shuai Li, Karina Ramirez, Xiaomei Xia, Yanhong Cao, Hanqiu Zhao, Ankit Tripathi, Shenfeng Qiu, Mrinalini Kala and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Bin LiuDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.ORCID 0000-0003-0467-3678
Dan YiDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.ORCID 0000-0002-2614-5027
Shuai LiDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.
Karina RamirezDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.
Xiaomei XiaDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.
Yanhong CaoDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.
Hanqiu ZhaoDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.
Ankit TripathiDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.
Shenfeng QiuTranslational Cardiovascular Research Center, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Mrinalini KalaDepartment of Internal Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Ruslan RafikovDepartment of Medicine, Indiana University College of Medicine, Indianapolis, IN, USA.
Haiwei GuCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Vinicio de Jesus PerezDivision of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA.ORCID 0000-0001-5532-8247
Sarah-Eve LemayPulmonary Hypertension and Vascular Biology Research Group, Faculty of Medicine, Laval University, Quebec, QC, Canada.
Christopher C GlembotskiDepartment of Internal Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.ORCID 0000-0002-1380-5073
Kenneth S KnoxDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.
Sebastien BonnetPulmonary Hypertension and Vascular Biology Research Group, Faculty of Medicine, Laval University, Quebec, QC, Canada.ORCID 0000-0001-5753-1900
Vladimir V KalinichenkoDivision of Neonatology, Phoenix Children's Hospital, Phoenix, AZ, USA.
You-Yang ZhaoProgram for Lung and Vascular Biology and Section for Injury Repair and Regeneration Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Michael B FallonDepartment of Internal Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Olivier BoucheratPulmonary Hypertension and Vascular Biology Research Group, Faculty of Medicine, Laval University, Quebec, QC, Canada.
Zhiyu DaiDivision of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, AZ, USA.ORCID 0000-0002-2945-7923
University of Arizona · USUniversité Laval · CAArizona State University · USIndiana University – Purdue University Indianapolis · USNorthwestern University · USStanford University · US

Funding

Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
Anaplerotic reprogramming of endothelial cells in pulmonary hypertension.R01HL132918 · NHLBI · UNIVERSITY OF ARIZONA · PI RAFIKOV, RUSLAN · 2016 to 2025
$4.5M
Hemolysis and Free Heme Signaling in Pulmonary HypertensionR01HL151447 · NHLBI · UNIVERSITY OF ARIZONA · PI Ruslan Rafikov · 2020 to 2026
$4.3M
Novel alveolar mechanisms of hypoxemia in hepatopulmonary syndromeR01HL169509 · NHLBI · UNIVERSITY OF ARIZONA · PI Zhiyu Dai, MICHAEL B FALLON · 2023 to 2026
$3.0M
General Capillary to Arterial Endothelial Cell Transition in Pulmonary ArterialHypertensionR01HL170096 · NHLBI · WASHINGTON UNIVERSITY · PI Zhiyu Dai · 2023 to 2026
$2.9M
Role of Endothelial SOX17 Deficiency in the Pathogenesis of Pulmonary HypertensionR01HL158596 · NHLBI · WASHINGTON UNIVERSITY · PI Zhiyu Dai · 2022 to 2026
$2.3M
Role of Smooth Muscle Progenitor Cells in Obliterative Vascular Remodeling and PHR00HL138278 · NHLBI · UNIVERSITY OF ARIZONA · PI DAI, ZHIYU · 2019 to 2021
$747k
NHLBI NIH HHS R00 HL138278NHLBI NIH HHS R01 HL132918NHLBI NIH HHS R01 HL151447NHLBI NIH HHS R01 HL158596NHLBI NIH HHS R01 HL169509NHLBI NIH HHS R01 HL170096NHLBI NIH HHS R24 HL123767
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a devastating disease characterized by obliterative vascular remodeling and persistent increase of vascular resistance, leading to right heart failure and premature death. Understanding the cellular and molecular mechanisms will help develop novel therapeutic approaches for PAH patients. Single-cell RNA sequencing (scRNAseq) analysis found that both FABP4 and FABP5 were highly induced in endothelial cells (ECs) of

Indexed as

arterialglycolysishypoxialipid metabolismright heart failure

Identifiers

PMID38370670
PMCPMC10871348
OpenAlexW4391754110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.