ArticlebioRxiv : the preprint server for biology2024
Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling.
Travis E Faust, Yi-Han Lee, Ciara D O'Connor, Margaret A Boyle, Georgia Gunner, Ana Badimon, Pinar Ayata, Anne Schaefer, Dorothy P Schafer
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 11 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 5 institutions in 3 countries.
Travis E FaustDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-4567-8435 Yi-Han LeeDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Ciara D O'ConnorDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Margaret A BoyleDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Georgia GunnerDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Ana BadimonNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Pinar AyataNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-7621-832X Anne SchaeferNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dorothy P SchaferDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
University of Massachusetts Chan Medical School · USHarvard University · USMax Planck Institute for Biology of Ageing · DERockefeller University · USThe Graduate Center, CUNY · US
Funding
Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2019 to 2026
$16.5MNeuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's diseaseR01AG072489 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALISON M GOATE, Anne Schaefer · 2022 to 2026
$6.3MMicroglia-dependent mechanisms governing neural circuit plasticityR01MH113743 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dorothy Patricia Schafer · 2017 to 2026
$4.9MAge-dependent activation of microglia inflammatory state and its epigenetic modulationRF1AG068558 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE, TARAKHOVSKY, ALEXANDER · 2020 to 2020
$3.0MResearch Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0MInnate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5MHow Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA · 2021 to 2025
$2.2MMicroglia mediated suppression of dopamine induced neuronal responses and behaviorR01MH118329 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE · 2019 to 2023
$2.1MTranscriptional Control of Microglia Diversification and InflammationR01NS106721 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE, TARAKHOVSKY, ALEXANDER · 2020 to 2024
$2.0MDissecting the impact of senescence on microglia function and neurodegenerationRF1AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2020 to 2020
$1.7MAge-dependent activation of microglia inflammatory state and its epigenetic modulationR01AG068558 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE, TARAKHOVSKY, ALEXANDER · 2024 to 2024
$726kDissecting ADAM10 function in microglia-mediated synapse eliminationF31NS117053 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GUNNER, GEORGIA · 2020 to 2021
$49kNIAID NIH HHS T32 AI095213NIA NIH HHS R01 AG072489NIA NIH HHS RF1 AG068281NIA NIH HHS RF1 AG068558NIA NIH HHS T32 AG049688NIDA NIH HHS P01 DA047233NIMH NIH HHS R01 MH113743NIMH NIH HHS R01 MH118329NINDS NIH HHS F31 NS117053NINDS NIH HHS R01 NS106721NINDS NIH HHS R01 NS117533
6 · The paper itselfAbstract
Astrocytes and microglia are emerging key regulators of activity-dependent synapse remodeling that engulf and remove synapses in response to changes in neural activity. Yet, the degree to which these cells communicate to coordinate this process remains an open question. Here, we use whisker removal in postnatal mice to induce activity-dependent synapse removal in the barrel cortex. We show that astrocytes do not engulf synapses in this paradigm. Instead, astrocytes reduce their contact with synapses prior to microglia-mediated synapse engulfment. We further show that reduced astrocyte-contact with synapses is dependent on microglial CX3CL1-CX3CR1 signaling and release of Wnts from microglia following whisker removal. These results demonstrate an activity-dependent mechanism by which microglia instruct astrocyte-synapse interactions, which then provides a permissive environment for microglia to remove synapses. We further show that this mechanism is critical to remodel synapses in a changing sensory environment and this signaling is upregulated in several disease contexts.
Indexed as
astrocyteMicrogliasynapse remodelingWnt
Identifiers
PMID38370645
PMCPMC10871360
OpenAlexW4391692411
What OpenQuestion holds
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LicenceCC BY
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