Evidence map›Paper›PMID 38370634›Full record

ArticlebioRxiv : the preprint server for biology2024

Transcription Factor Condensates Mediate Clustering of

James Lee, Leman Simpson, Yi Li, Samuel Becker, Fan Zou, Xin Zhang, Lu Bai

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

James LeeDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Leman SimpsonCenter for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA, 16802, USA.
Yi LiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Samuel BeckerDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Fan ZouDepartment of Physics, The Pennsylvania State University, University Park, PA, 16802, USA.
Xin ZhangDepartment of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA.
Lu BaiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.ORCID 0000-0003-3667-2944
Pennsylvania State University · US

Funding

Mechanism of Chromatin Accessibility, 3D Chromosome Organization, and Their Functions in Gene RegulationR35GM139654 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Lu Bai · 2021 to 2026
$3.8M
NIGMS NIH HHS R35 GM139654
6 · The paper itself

Abstract

Some transcription factors (TFs) can form liquid-liquid phase separated (LLPS) condensates. However, the functions of these TF condensates in 3D genome organization and gene regulation remain elusive. In response to methionine (met) starvation, budding yeast TF Met4 and a few co-activators, including Met32, induce a set of genes involved in met biosynthesis. Here, we show that the endogenous Met4 and Met32 form co-localized puncta-like structures in yeast nuclei upon met depletion. Recombinant Met4 and Met32 form mixed droplets with LLPS properties

Identifiers

PMID38370634
PMCPMC10871269
OpenAlexW4391792324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.