Evidence map›Paper›PMID 38370632›Full record

ArticlebioRxiv : the preprint server for biology2024

A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects.

Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathon M Muncie-Vasic, W Patrick Devine, Kevin M Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Irfan S KathiriyaDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.ORCID 0000-0003-1207-1490
Martin H DominguezGladstone Institutes, San Francisco, CA.
Kavitha S RaoDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.ORCID 0000-0001-5401-6989
Jonathon M Muncie-VasicGladstone Institutes, San Francisco, CA.
W Patrick DevineGladstone Institutes, San Francisco, CA.
Kevin M HuDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
Swetansu K HotaGladstone Institutes, San Francisco, CA.ORCID 0000-0003-3105-9729
Bayardo I GarayDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
Diego QuinteroGladstone Institutes, San Francisco, CA.
Piyush GoyalDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
Megan N MatthewsDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
Reuben ThomasGladstone Institutes, San Francisco, CA.
Tatyana SukonnikGladstone Institutes, San Francisco, CA.
Dario Miguel-PerezGladstone Institutes, San Francisco, CA.
Sarah WinchesterGladstone Institutes, San Francisco, CA.
Emily F BrowerGladstone Institutes, San Francisco, CA.
André ForjazDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD.
Pei-Hsun WuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD.
Denis WirtzDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD.
Ashley L KiemenDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD.
Benoit G BruneauGladstone Institutes, San Francisco, CA.ORCID 0000-0002-0804-7597
Gladstone Institutes · USJohns Hopkins University · USUniversity of California, San Francisco · USCreighton University · US

Funding

Tech Core 2U54CA268083 · NCI · JOHNS HOPKINS UNIVERSITY · PI Pei-Hsun wu · 2022 to 2026
$10.2M
Early Cardiac ProgenitorsR01HL114948 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI Benoit Gaetan Bruneau · 2013 to 2026
$7.5M
The Epigenetic Landscape of Heart DevelopmentUM1HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, POLLARD, KATHERINE S. · 2015 to 2019
$4.7M
Gene regulatory networks for heart developmentR01HL155906 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN · 2021 to 2024
$2.4M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1M
Three-dimensional maps of senescence in the human pancreasUG3CA275681 · NCI · JOHNS HOPKINS UNIVERSITY · PI WU, PEI-HSUN · 2022 to 2023
$1.1M
Patterning Mechanisms for Ventricular Septation and Congenital Heart DiseaseR56HL166894 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATHIRIYA, IRFAN S · 2024 to 2024
$605k
Uncovering the Mechanisms that Enable Cardiac Progenitors to Build the Linear Heart TubeK99HL177318 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI Jonathon Michael Muncie-Vasic · 2025 to 2026
$270k
Defining the Cellular Morphogenic Behaviors that Shape the Developing HeartF32HL162450 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI MUNCIE-VASIC, JONATHON MICHAEL · 2022 to 2023
$137k
NCI NIH HHS U54 CA268083NCI NIH HHS UG3 CA275681NCRR NIH HHS C06 RR018928NHLBI NIH HHS F32 HL162450NHLBI NIH HHS K99 HL177318NHLBI NIH HHS R01 HL114948NHLBI NIH HHS R01 HL155906NHLBI NIH HHS R56 HL166894NHLBI NIH HHS UM1 HL098179
6 · The paper itself

Abstract

Failure of septation of the interventricular septum (IVS) is the most common congenital heart defect (CHD), but mechanisms for patterning the IVS are largely unknown. We show that a

Identifiers

PMID38370632
PMCPMC10871243
OpenAlexW4391568908

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.