Evidence map›Paper›PMID 38370613›Full record

ArticlebioRxiv : the preprint server for biology2024

Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost.

Clinton A Elg, Erin Mack, Michael Rolfsmeier, Thomas C McLean, Olivia Kosterlitz, Elizabeth Soderling, Solana Narum, Paul A Rowley, Christopher M Thomas, Eva M Top

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Clinton A ElgBioinformatics and Computational Biology Program, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0001-5468-395X
Erin MackDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-8893-0792
Michael RolfsmeierDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Thomas C McLeanDepartment of Molecular Microbiology, John Innes Centre, Norwich, UK.ORCID 0000-0002-6467-4974
Olivia KosterlitzInstitute for Interdisciplinary Data Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-8692-9595
Elizabeth SoderlingDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Solana NarumBioinformatics and Computational Biology Program, University of Idaho, Moscow, Idaho, USA.ORCID 0009-0001-6559-7288
Paul A RowleyDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-3590-5139
Christopher M ThomasSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK.ORCID 0000-0002-2810-0455
Eva M TopBioinformatics and Computational Biology Program, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-6380-8782
University of Idaho · USJohn Innes Centre · GBUniversity of Birmingham · GB

Funding

THE ORIGIN AND SPREAD OF MOSAIC PLASMIDS ENCODING MULTI-DRUG RESISTANCE(Research Supplement to Promote Diversity)R01AI084918 · NIAID · UNIVERSITY OF IDAHO · PI TOP, EVA M. · 2010 to 2022
$3.6M
NIAID NIH HHS R01 AI084918Wellcome Trust
6 · The paper itself

Abstract

Plasmids play a major role in rapid adaptation of bacteria by facilitating horizontal transfer of diverse genes, most notably those conferring antibiotic resistance. While most plasmids that replicate in a broad range of bacteria also persist well in diverse hosts, there are exceptions that are poorly understood. We investigated why a broad-host range plasmid, pBP136, originally found in clinical

Identifiers

PMID38370613
PMCPMC10871194
OpenAlexW4391609242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.