Evidence map›Paper›PMID 38370393›Full record

ArticleEuropean heart journal. Imaging methods and practice2024

Molecular magnetic resonance imaging of myeloperoxidase activity identifies culprit lesions and predicts future atherothrombosis.

James Nadel, Xiaoying Wang, Prakash Saha, André Bongers, Sergey Tumanov, Nicola Giannotti, Weiyu Chen, Niv Vigder, Mohammed M Chowdhury, Gastao Lima da Cruz and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Imaging methods and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Molecular imaging of atherosclerotic plaque vulnerability: a narrative review.The international journal of cardiovascular imaging · 2026
    Review
  2. Article
  3. Cardiovascular imaging in 2024: review of current research and innovations.European heart journal. Imaging methods and practice · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

James NadelHeart Research Institute, Arterial Inflammation and Redox Biology Group, 7 Eliza St, Newtown, Sydney, NSW 2042, Australia.
Xiaoying WangSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Prakash SahaAcademic Department of Surgery, Cardiovascular Division, King's College London, London, UK.
André BongersBiological Resources Imaging Laboratory, University of New South Wales, Sydney, NSW, Australia.
Sergey TumanovHeart Research Institute, Arterial Inflammation and Redox Biology Group, 7 Eliza St, Newtown, Sydney, NSW 2042, Australia.
Nicola GiannottiMedical Imaging Science, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Weiyu ChenHeart Research Institute, Arterial Inflammation and Redox Biology Group, 7 Eliza St, Newtown, Sydney, NSW 2042, Australia.
Niv VigderHeart Research Institute, Arterial Inflammation and Redox Biology Group, 7 Eliza St, Newtown, Sydney, NSW 2042, Australia.
Mohammed M ChowdhuryDepartment of Vascular Surgery, University of Cambridge, Cambridge, UK.
Gastao Lima da CruzDepartment of Radiology, University of Michigan, Ann Arbor, USA.
Carlos VelascoSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Claudia PrietoSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Andrew JabbourDepartment of Cardiology, St Vincent's Hospital, Sydney, NSW, Australia.
René M BotnarSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Roland StockerHeart Research Institute, Arterial Inflammation and Redox Biology Group, 7 Eliza St, Newtown, Sydney, NSW 2042, Australia.ORCID https://orcid.org/0000-0002-7414-6681
Alkystis PhinikaridouSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-5687-8504
King's College London · GBThe Heart Research Institute · AUPontificia Universidad Católica de Chile · CLThe University of Sydney · AUUNSW Sydney · AUUniversity of Cambridge · GBUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Unstable atherosclerotic plaques have increased activity of myeloperoxidase (MPO). We examined whether molecular magnetic resonance imaging (MRI) of intraplaque MPO activity predicts future atherothrombosis in rabbits and correlates with ruptured human atheroma. Methods and results: Plaque MPO activity was assessed Conclusion: We show that elevated intraplaque MPO activity detected by molecular MRI employing MPO-Gd predicts future atherothrombosis in a rabbit model and detects ruptured human atheroma, strengthening the translational potential of this approach to prospectively detect high-risk atherosclerosis.

Indexed as

atherosclerosisatherothrombosiscarotid endarterectomymolecular magnetic resonance imagingmyeloperoxidaseplaque disruption

Identifiers

PMID38370393
PMCPMC10870993
OpenAlexW4391211867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.