Evidence map›Paper›PMID 38370336›Full record

ReviewNorth American Spine Society journal2024

The prevalence of vertebral fractures in diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis: A systematic review and meta-analysis.

Netanja I Harlianto, Solaiman Ezzafzafi, Wouter Foppen, Jonneke S Kuperus, Irene E van der Horst-Bruinsma, Pim A de Jong, Jorrit-Jan Verlaan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in North American Spine Society journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Rethinking fracture "prevalence" and risk stratification in ankylosing spondylitis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Netanja I HarliantoDepartment of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
Solaiman EzzafzafiDepartment of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
Wouter FoppenDepartment of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
Jonneke S KuperusDepartment of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
Irene E van der Horst-BruinsmaDepartment of Rheumatology, Radboud UMC, Nijmegen, The Netherlands.
Pim A de JongDepartment of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
Jorrit-Jan VerlaanDepartment of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
Utrecht University · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Subjects with ankylosing spinal disorders, including diffuse idiopathic skeletal hyperostosis (DISH) and ankylosing spondylitis (AS) are more prone to vertebral fractures and frequently present with neurological deficit compared to the patients without an ankylosed spine. Moreover, prevalent vertebral fractures are an important predictor for subsequent fracture risk. However, the pooled fracture prevalence for DISH is unknown and less recent for AS. We aimed to systematically investigate the prevalence and risk of vertebral fractures in DISH and AS populations. Methods: Publications in Medline and EMBASE were searched from January 1980 until July 2023 for cohort studies reporting vertebral fractures in AS and DISH. Data on prevalence were pooled with random effects modeling after double arcsine transformation. Heterogeneity was assessed with I Results: We included 7 studies on DISH (n = 1,193, total fractures = 231) with a pooled vertebral fracture prevalence of 22.6% (95%CI: 13.4%-33.4%). For AS, 26 studies were included (n = 2,875, total fractures = 460) with a pooled vertebral fracture prevalence of 15.2% (95%CI: 11.6%-19.1%). In general, fracture prevalence for AS remained similar for several study-level and clinically relevant characteristics, including study design, diagnostic criteria, spine level, and patient characteristics in subgroup analysis. AS publications from 2010 to 2020 showed higher fracture prevalence compared to 1990 to 2010 (18.6% vs. 11.6%). Fractures in DISH were most common at the thoracolumbar junction, whereas for AS, the most common location was the mid-thoracic spine. Conclusions: Vertebral fractures are prevalent in AS and DISH populations. Differences in fracture distribution along the spinal axis exist between the 2 disorders. Additional longitudinal studies are needed for incident fracture assessment in patients with ankylosing spinal disorders.

Indexed as

Ankylosing spondylitisComputed tomographyDiffuse idiopathic skeletal hyperostosisFractureMorbus bechterewMorbus forestierRadiographySpondylarthitisVertebral fracture

Identifiers

PMID38370336
PMCPMC10869944
OpenAlexW4391071213

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.