ArticleIBRO neuroscience reports2024
Is the Papez circuit the location of the elusive episodic memory engram?
Article in IBRO neuroscience reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification and diagnosis of ultra-rapid progressive dementia: evidence from a prospective cohort study and systematic literature review.Journal of neurology · 2024Pooled it
- Structural Connectivity of Functionally Defined Episodic Memory Networks: A Large-Scale Connectome-Behavior Study.Brain and behavior · 2026Article
- Neural correlates of Parkinson's improvements after combined digital-levodopa therapy: a pilot study.Brain communications · 2026Article
- Impact of effective connectivity within the Papez circuit on episodic memory: moderation by perivascular space function.Alzheimer's research & therapy · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
All of the brain structures and white matter that make up Papez' circuit, as well as the circuit as a whole, are implicated in the literature in episodic memory formation and recall. This paper shows that Papez' circuit has the detailed structure and connectivity that is evidently required to support the episodic memory engram, and that identifying Papez' circuit as the location of the engram answers a number of long-standing questions regarding the role of medial temporal lobe structures in episodic memory. The paper then shows that the process by which the episodic memory engram may be formed is a network-wide Hebbian potentiation termed "racetrack potentiation", whose frequency corresponds to that observed in vivo in humans for memory functions. Further, by considering the microcircuits observed in the medial temporal lobe structures forming Papez' circuit, the paper establishes the neural mechanisms behind the required functions of sensory information storage and recall, pattern completion, pattern separation, and memory consolidation. The paper shows that Papez' circuit has the necessary connectivity to gather the various elements of an episodic memory occurring within Pöppel's experienced time or "quantum of experience". Finally, the paper shows how the memory engram located in Papez' circuit might be central to the formation of a duplicate engram in the cortex enabling consolidation and long-term storage of episodic memories.
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Registered trials
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