Evidence map›Paper›PMID 38369603›Full record

ArticleScientific reports2024

Association between failed eradication of 7-day triple therapy for Helicobacter pylori and untreated dental caries in Japanese adults.

Komei Iwai, Tetsuji Azuma, Takatoshi Yonenaga, Yasuyuki Sasai, Kazutoshi Watanabe, Akihiro Obora, Fumiko Deguchi, Takao Kojima, Takaaki Tomofuji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Polymicrobial interactions ofJournal of oral microbiology · 2025
    Review
  4. Review
  5. Association Between Oral Health and Gastric Cancer in Korean Adults.The Korean journal of helicobacter and upper gastrointestinal research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Komei IwaiDepartment of Community Oral Health, School of Dentistry, Asahi University, 1851-1 Hozumi, Mizuho, Gifu, 501-0296, Japan.
Tetsuji AzumaDepartment of Community Oral Health, School of Dentistry, Asahi University, 1851-1 Hozumi, Mizuho, Gifu, 501-0296, Japan.
Takatoshi YonenagaDepartment of Community Oral Health, School of Dentistry, Asahi University, 1851-1 Hozumi, Mizuho, Gifu, 501-0296, Japan.
Yasuyuki SasaiDepartment of Community Oral Health, School of Dentistry, Asahi University, 1851-1 Hozumi, Mizuho, Gifu, 501-0296, Japan.
Kazutoshi WatanabeAsahi University Hospital, 3-23 Hashimoto-Cho, Gifu, Gifu, 500-8523, Japan.
Akihiro OboraAsahi University Hospital, 3-23 Hashimoto-Cho, Gifu, Gifu, 500-8523, Japan.
Fumiko DeguchiAsahi University Hospital, 3-23 Hashimoto-Cho, Gifu, Gifu, 500-8523, Japan.
Takao KojimaAsahi University Hospital, 3-23 Hashimoto-Cho, Gifu, Gifu, 500-8523, Japan.
Takaaki TomofujiDepartment of Community Oral Health, School of Dentistry, Asahi University, 1851-1 Hozumi, Mizuho, Gifu, 501-0296, Japan. tomofu@dent.asahi-u.ac.jp.ORCID https://orcid.org/0000-0001-5608-7430
Asahi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori (H. pylori) infection is a cause of gastric disorders and is treated mainly by pharmacotherapy with antimicrobial agents. An association has been reported between dental caries and H. pylori infection. As antimicrobial agents are less effective inside dental caries because of impaired blood circulation, the presence of untreated dental caries (decayed teeth) may influence the success of H. pylori eradication treatment. In this cross-sectional study, we examined whether failed eradication of H. pylori was associated with decayed teeth in Japanese adults. Enrolled were 226 participants who received dental checkups among those treated for eradication of H. pylori at Asahi University Hospital between April 2019 and March 2021. Treatment efficacy was assessed by urea breath test. Eradication failed in 38 participants (17%), decayed teeth in 32 participants (14%), and number of 0.34 teeth per participants. Multivariate logistic regression analyses showed that failed eradication of H. pylori was associated with decayed teeth (presence: odds ratio, 2.672; 95% confidence interval, 1.093-6.531) after adjusting for gender, age, and brushing frequency. These results indicate that failed eradication of H. pylori was associated with decayed teeth and suggest that untreated dental caries may impact treatment for eradication of H. pylori.

Indexed as

Anti-Infective AgentsDental CariesHelicobacter InfectionsHelicobacter pyloriAdultAnti-Bacterial AgentsClarithromycinCross-Sectional StudiesDrug Therapy, CombinationHumansJapanTreatment OutcomeAnti-Bacterial AgentsAnti-Infective AgentsClarithromycin

Identifiers

PMID38369603
PMCPMC10874953
OpenAlexW4391946166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.