Evidence map›Paper›PMID 38369598›Full record

SynthesisNeurosurgical review2024

Efficacy of growth factor gene-modified stem cells for motor function after spinal cord injury in rodents: a systematic review and meta‑analysis.

Wen-Ya Shang, Ya-Feng Ren, Bing Li, Xiao-Meng Huang, Zhi-Lan Zhang, Jing Huang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wen-Ya ShangHenan University of Chinese Medicine, Zhengzhou, China.
Ya-Feng RenThe First Affiliated Hospital of Henan University of CM, Zhengzhou, China. 253453490@qq.com.
Bing LiThe First Affiliated Hospital of Henan University of CM, Zhengzhou, China.
Xiao-Meng HuangHenan University of Chinese Medicine, Zhengzhou, China.
Zhi-Lan ZhangHenan University of Chinese Medicine, Zhengzhou, China.
Jing HuangHenan University of Chinese Medicine, Zhengzhou, China.
First Affiliated Hospital of Henan University · CNFirst Affiliated Hospital of Henan University of Traditional Chinese Medicine · CN

Funding

Special Project of Scientific Research on Traditional Chinese Medicine in Henan Province Grant number 2022JDZX015
6 · The paper itself

Abstract

The efficacy of growth factor gene-modified stem cells in treating spinal cord injury (SCI) remains unclear. This study aims to evaluate the effectiveness of growth factor gene-modified stem cells in restoring motor function after SCI. Two reviewers searched four databases, including PubMed, Embase, Web of Science, and Scopus, to identify relevant records. Studies on rodents assessing the efficacy of transplanting growth factor gene-modified stem cells in restoring motor function after SCI were included. The results were reported using the standardized mean difference (SMD) with a 95% confidence interval (95% CI). Analyses showed that growth factor gene-modified stem cell transplantation improved motor function recovery in rodents with SCI compared to the untreated (SMD = 3.98, 95% CI 3.26-4.70, I

Indexed as

Recovery of FunctionSpinal Cord InjuriesStem Cell TransplantationAnimalsHumansIntercellular Signaling Peptides and ProteinsNeural Stem CellsRatsRodentiaIntercellular Signaling Peptides and ProteinsGenetic engineeringGrowth factorMeta-analysisSpinal cord injuriesStem cell

Identifiers

PMID38369598
OpenAlexW4391929254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.