Evidence map›Paper›PMID 38369472›Full record

ArticleJournal of nanobiotechnology2024

Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling.

Martina Trentini, Ilaria Zanolla, Elena Tiengo, Federica Zanotti, Eduardo Sommella, Fabrizio Merciai, Pietro Campiglia, Danilo Licastro, Margherita Degasperi, Luca Lovatti and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

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  4. Apple-Derived Vesicles Orchestrate Bone Regeneration:International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Martina TrentiniDepartment Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.
Ilaria ZanollaDepartiment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Elena TiengoDepartment Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.
Federica ZanottiDepartment Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.
Eduardo SommellaDepartment of Pharmacy, University of Salerno, 84084, Fisciano, SA, Italy.
Fabrizio MerciaiDepartment of Pharmacy, University of Salerno, 84084, Fisciano, SA, Italy.
Pietro CampigliaDepartment of Pharmacy, University of Salerno, 84084, Fisciano, SA, Italy.
Danilo LicastroAREA Science Park, Padriciano, 99, 34149, Trieste, Italy.
Margherita DegasperiAREA Science Park, Padriciano, 99, 34149, Trieste, Italy.
Luca LovattiDepartment Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.
Massimo BonoraDepartiment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Alberto DaneseDepartiment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Paolo PintonDepartiment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Barbara ZavanDepartment Translational Medicine, University of Ferrara, 44121, Ferrara, Italy. barbara.zavan@unife.it.
University of Ferrara · ITUniversity of Salerno · ITAREA Science Park · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlant-derived nanovesicles (PDNVs) are a novelty in medical and agrifood environments, with several studies exploring their functions and potential applications. Among fruits, apples (sp. Malus domestica) have great potential as PDNVs source, given their widespread consumption, substantial waste production, and recognized health benefits. Notably, apple-derived nanovesicles (ADNVs) can interact with human cell lines, triggering anti-inflammatory and antioxidant responses. This work is dedicated to the comprehensive biochemical characterization of apple-derived nanovesicles (ADNVs) through proteomic and lipidomic analysis, and small RNAs sequencing. This research also aims to shed light on the underlying mechanism of action (MOA) when ADNVs interface with human cells, through observation of intracellular calcium signalling in human fibroblasts, and to tackles differences in ADNVs content when isolated from fruits derived from integrated and organic production methods cultivars.

resultsThe ADNVs fraction is mainly composed of exocyst-positive organelles (EXPOs) and MVB-derived exosomes, identified through size and molecular markers (Exo70 and TET-3-like proteins). ADNVs' protein cargo is heterogeneous and exhibits a diverse array of functions, especially in plant's protection (favouring ABA stress-induced signalling, pathogen resistance and Reactive Oxygen Species (ROS) metabolism). Noteworthy plant miRNAs also contribute to phytoprotection. In relation with human cells lines, ADNVs elicit spikes of intracellular Ca

conclusionsWe have conclusively demonstrated that ADNVs confer an antioxidant effect upon human cells, through the initiation of a molecular pathway triggered by Ca

Indexed as

AntioxidantsMalusCalciumHumansProteomicsSignal TransductionVegetablesAntioxidantsCalciumApple-derived extracellular vesiclesCalcium signallingLipidomicmiRNAPlant-derived extracellular vesiclesProteomic

Identifiers

PMID38369472
PMCPMC10875884
OpenAlexW4391919390

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.