Evidence map›Paper›PMID 38369459›Full record

ArticleJournal of orthopaedic surgery and research2024

Periostin/Bone Morphogenetic Protein 1 axis axis regulates proliferation and osteogenic differentiation of sutured mesenchymal stem cells and affects coronal suture closure in the TWIST1

ShuBin Feng, Qiang Feng, LiuJian Dong, Qiang Lv, ShiYue Mei, YaoDong Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

ShuBin FengDepartment of Neurosurgery, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, Zhengzhou City, 450018, Henan Province, China.
Qiang FengDepartment of Neurosurgery, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, Zhengzhou City, 450018, Henan Province, China.
LiuJian DongDepartment of Neurosurgery, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, Zhengzhou City, 450018, Henan Province, China.
Qiang LvDepartment of Neurosurgery, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, Zhengzhou City, 450018, Henan Province, China.
ShiYue MeiHenan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, No.33, Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou City, 450018, Henan Province, China.
YaoDong ZhangHenan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, No.33, Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou City, 450018, Henan Province, China. zydsyek1292@hotmail.com.
Zhengzhou Children's Hospital · CN

Funding

Henan Provincial Medical Science and Technology Research Plan jointly construction project NO. LHGJ20210646
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe pathogenesis of coronal suture craniosynostosis is often attributed to the dysregulated cellular dynamics, particularly the excessive proliferation and abnormal osteogenic differentiation of suture cells. Despite its clinical significance, the molecular mechanims of this condition remain inadequately understood. This study is dedicated to exploring the influence of the Periostin/Bone Morphogenetic Protein 1 (BMP1) axis on the growth and osteogenic maturation of Suture Mesenchymal Stem Cells (SMSCs), which are pivotal in suture homeostasis.

methodsNeonatal TWIST Basic Helix-Loop-Helix Transcription Factor 1 heterozygous (TWIST1

resultsIn the TWIST1

conclusionThese findings underscore the significance of the Periostin/BMP1 axis in regulating craniosynostosis and SMSC functions, providing new insights into the molecular mechanisms of craniosynostosis and potential targets for therapeutic intervention.

Indexed as

CraniosynostosesMesenchymal Stem CellsAnimalsBone Morphogenetic Protein 1Cell DifferentiationCell ProliferationCells, CulturedDisease Models, AnimalMiceOsteogenesisPeriostinBone Morphogenetic Protein 1PeriostinBMP1Coronal suture closureCraniosynostosisOsteogenesisPeriostin

Identifiers

PMID38369459
PMCPMC10875791
OpenAlexW4391942906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.