Evidence map›Paper›PMID 38369434›Full record

ReviewTrends in biotechnology2024

Beyond waste: understanding urine's potential in precision medicine.

Pengfei Yu, Carol Christine Bosholm, Hainan Zhu, Zhongping Duan, Anthony Atala, Yuanyuan Zhang

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pengfei YuThe Fourth Department of Liver Disease, Beijing YouAn Hospital, Capital Medical University, Beijing, China; Wake Forest Institute for Regeneration Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Carol Christine BosholmWake Forest Institute for Regeneration Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Hainan ZhuWake Forest Institute for Regeneration Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Zhongping DuanThe Fourth Department of Liver Disease, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Anthony AtalaWake Forest Institute for Regeneration Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Yuanyuan ZhangWake Forest Institute for Regeneration Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: yzhang@wakehealth.edu.

Funding

3D Culture Systems Of Urine-Derived Stem Cell For NTRI-Induced Mitotoxicity AssessmentR21AI152832 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2020 to 2021
$426k
Regeneration of human RPE cells from autologous urine-derived iPS cellsR21EY035833 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2024 to 2025
$426k
Bone Marrow Stromal Cells for Bladder Tissue EngineeringR21DK071791 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2005 to 2006
$355k
Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity TestingR03AI165170 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2021 to 2022
$155k
Stem Cell Therapy Combined with Growth Factors for Stress Urinary IncontinenceR56DK100669 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2014 to 2014
$116k
NEI NIH HHS R21 EY035833NIAID NIH HHS R03 AI165170NIAID NIH HHS R21 AI152832NIDDK NIH HHS R21 DK071791NIDDK NIH HHS R56 DK100669
6 · The paper itself

Abstract

Urine-derived stem cells (USCs) are a promising source of stem cells for cell therapy, renal toxicity drug testing, and renal disease biomarker discovery. Patients' own USCs can be used for precision medicine. In this review we first describe the isolation and characterization of USCs. We then discuss preclinical studies investigating the use of USCs in cell therapy, exploring the utility of USCs and USC-derived induced pluripotent stem cells (u-iPSCs) in drug toxicity testing, and investigating the use of USCs as biomarkers for renal disease diagnosis. Finally, we discuss the challenges of using USCs in these applications and provide insights into future research directions. USCs are a promising tool for advancing renal therapy, drug testing, and biomarker discovery. Further research is needed to explore their potential.

Indexed as

Precision MedicineUrineAnimalsBiomarkersCell- and Tissue-Based TherapyHumansInduced Pluripotent Stem CellsKidney DiseasesStem CellsBiomarkerscell therapydrug testingnephrotoxicitystem cellstissue repairurine

Identifiers

PMID38369434
PMCPMC11741143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.