Evidence map›Paper›PMID 38369357›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Ventral Variant Posterior Cortical Atrophy with Occipito-temporal Accumulation of Tau Proteins/Astrocyte Gliosis.

Mihoko Shiio, Nobuya Maeda, Atsushi Iwata, Kenji Ishibashi, Kenji Ishii, Hiroshi Takuma, Yuko Ishizaka, Yasuhisa Sakurai

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mihoko ShiioDepartment of Neurology, Omori Red Cross Hospital, Japan.
Nobuya MaedaDepartment of Neurology, Omori Red Cross Hospital, Japan.
Atsushi IwataDepartment of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan.
Kenji IshibashiTeam for Neuroimaging Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan.
Kenji IshiiTeam for Neuroimaging Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan.
Hiroshi TakumaTakuma Neurology Clinic, Japan.
Yuko IshizakaDepartment of Health Care, Mitsui Memorial Hospital, Japan.
Yasuhisa SakuraiTakuma Neurology Clinic, Japan.
Tokyo Metropolitan Institute of Gerontology · JPOkayama Psychiatric Medical Center · JPMitsui Memorial Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 73-year-old woman with posterior cortical atrophy (PCA) presented with progressive apperceptive visual agnosia, alexia, agraphia, ventral simultanagnosia, prosopagnosia, and allocentric (stimulus-centered) left-sided hemispatial neglect. All of these symptoms were attributed to damage to the bilateral occipito-temporal cortices, consistent with ventral variant PCA. While the Pittsburgh compound B uptake was extensively distributed throughout the occipito-parietal (dorsal) and occipito-temporal (ventral) areas, the THK5351 (ligand binding to tau aggregates/astrocyte gliosis) accumulation was limited to the ventral area. These findings suggest that local accumulation of tau proteins and/or astrocyte gliosis over the occipito-temporal cortices can result in ventral variant PCA.

Indexed as

AstrocytesAtrophyGliosistau ProteinsAgedCarbolinesCerebral CortexFemaleHumansMagnetic Resonance ImagingOccipital LobeTemporal Lobe7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinestau Proteinsallocentric hemispatial neglectAlzheimer's diseaseposterior cortical atrophypure alexiaventral simultanagnosiavisual agnosia

Identifiers

PMID38369357
PMCPMC11473282
OpenAlexW4391921949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.