Evidence map›Paper›PMID 38369233›Full record

ArticleThe Journal of pediatrics2024

A Predictive Model for Thiamine Responsive Disorders Among Infants and Young Children: Results from a Prospective Cohort Study in Lao People's Democratic Republic.

Taryn J Smith, Charles D Arnold, Philip R Fischer, Indi Trehan, Laurent Hiffler, Dalaphone Sitthideth, Rebecca Stein-Wexler, Jay Yeh, Kerry S Jones, Daniela Hampel and 8 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03626337 (A Study to Establish a Case Definition of Thiamine Responsive Disorders), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03626337 completednot on this map

A Study to Establish a Case Definition of Thiamine Responsive Disorders (TRD) Among Infants in Lao PDR

TypeobservationalSponsorUniversity of California, DavisRan2019 to 2021Enrolled1,394ConditionsThiamine DeficiencyArmsThiamine 100 MG/ML
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Taryn J SmithInstitute for Global Nutrition and Department of Nutrition, University of California Davis, Davis, CA. Electronic address: taryn.smith@liverpool.ac.uk.
Charles D ArnoldInstitute for Global Nutrition and Department of Nutrition, University of California Davis, Davis, CA.
Philip R FischerDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Pediatrics Department, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Khalifa University, Abu Dhabi, United Arab Emirates.
Indi TrehanDepartments of Pediatrics, Global Health, and Epidemiology, University of Washington, Seattle, WA; Lao Friends Hospital for Children, Luang Prabang, Lao People's Democratic Republic.
Laurent HifflerCellular Nutrition Research Group, Lagny sur Marne, France.
Dalaphone SitthidethLao Tropical and Public Health Institute, Vientiane Capital, Lao People's Democratic Republic.
Rebecca Stein-WexlerDepartment of Radiology, University of California Davis Health System, Sacramento, CA.
Jay YehDepartment of Pediatrics, Division of Cardiology, University of California Davis Health System, Sacramento, CA.
Kerry S JonesNutritional Biomarker Laboratory, MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Daniela HampelInstitute for Global Nutrition and Department of Nutrition, University of California Davis, Davis, CA; USDA-Agricultural Research Service Western Human Nutrition Research Center, Davis, CA.
Daniel J TancrediDepartment of Pediatrics, University of California Davis Health System, Sacramento, CA.
Michael A SchickEmergency Medicine, University of California Davis Health System, Sacramento, CA.
Christine N McBethEmergency Medicine, University of California Davis Health System, Sacramento, CA.
Xiuping TanInstitute for Global Nutrition and Department of Nutrition, University of California Davis, Davis, CA.
Lindsay H AllenInstitute for Global Nutrition and Department of Nutrition, University of California Davis, Davis, CA; USDA-Agricultural Research Service Western Human Nutrition Research Center, Davis, CA.
Somphou SayasoneLao Tropical and Public Health Institute, Vientiane Capital, Lao People's Democratic Republic.
Sengchanh KounnavongLao Tropical and Public Health Institute, Vientiane Capital, Lao People's Democratic Republic.
Sonja Y HessInstitute for Global Nutrition and Department of Nutrition, University of California Davis, Davis, CA.
University of California, Davis · USUC Davis Health · USAgricultural Research Service · USKhalifa University of Science and Technology · AEUniversity of Cambridge · GBUniversity of Washington · US

Funding

Gates Foundation INV-009736
6 · The paper itself

Abstract

objectiveTo develop a predictive model for thiamine responsive disorders (TRDs) among infants and young children hospitalized with signs or symptoms suggestive of thiamine deficiency disorders (TDDs) based on response to therapeutic thiamine in a high-risk setting. STUDY

designChildren aged 21 days to <18 months hospitalized with signs or symptoms suggestive of TDD in northern Lao People's Democratic Republic were treated with parenteral thiamine (100 mg daily) for ≥3 days in addition to routine care. Physical examinations and recovery assessments were conducted frequently for 72 hours after thiamine was initiated. Individual case reports were independently reviewed by three pediatricians who assigned a TRD status (TRD or non-TRD), which served as the dependent variable in logistic regression models to identify predictors of TRD. Model performance was quantified by empirical area under the receiver operating characteristic curve.

resultsA total of 449 children (median [Q1, Q3] 2.9 [1.7, 5.7] months old; 70.3% exclusively/predominantly breastfed) were enrolled; 60.8% had a TRD. Among 52 candidate variables, those most predictive of TRD were exclusive/predominant breastfeeding, hoarse voice/loss of voice, cyanosis, no eye contact, and no diarrhea in the previous 2 weeks. The area under the receiver operating characteristic curve (95% CI) was 0.82 (0.78, 0.86).

conclusionsIn this study, the majority of children with signs or symptoms of TDD responded favorably to thiamine. While five specific features were predictive of TRD, the high prevalence of TRD suggests that thiamine should be administered to all infants and children presenting with any signs or symptoms consistent with TDD in similar high-risk settings. The usefulness of the predictive model in other contexts warrants further exploration and refinement.

trial registrationClinicaltrials.gov NCT03626337.

Indexed as

Southeast Asian PeopleThiamineThiamine DeficiencyFemaleHumansInfantInfant, NewbornLaosMaleProspective StudiesVitamin B ComplexThiamineVitamin B Complexberibericardiac distresscritical illnessencephalopathyrespiratory distressSoutheast Asiathiamine deficiencythiamine deficiency disorders

Identifiers

PMID38369233
PMCPMC11092315
OpenAlexW4392821700

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.