Evidence map›Paper›PMID 38368722›Full record

ArticleEpilepsy & behavior : E&B2024

Post-traumatic seizures and factors associated among adult patients with depressed skull fractures at Mulago National Referral hospital; cross-sectional study.

Ronald Oboth, Larrey Kasereka Kamabu, Herve M Lekuya, Godfrey S Bbosa, Martha Sajatovic, Elly Katabira, Mark Kaddumukasa, Moses Galukande

Open access · greenAbstract read
In one paragraph

Article in Epilepsy & behavior : E&B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ronald ObothDepartment of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda. Electronic address: obabdurazak@gmail.com.
Larrey Kasereka KamabuDepartment of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda.
Herve M LekuyaDepartment of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda.
Godfrey S BbosaDepartment of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Makerere University Kampala, Uganda.
Martha SajatovicNeurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Elly KatabiraDepartment of Internal Medicine, School of Medicine, College of Health Sciences, Makerere University, Uganda.
Mark KaddumukasaDepartment of Internal Medicine, School of Medicine, College of Health Sciences, Makerere University, Uganda.
Moses GalukandeDepartment of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda.
Makerere University · UGUniversity Hospitals of Cleveland · US

Funding

Research training and mentorship to strengthen brain health across the lifespan in Uganda.D43NS118560 · NINDS · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KADDUMUKASA, MARK, KATABIRA, ELLY T · 2020 to 2024
$1.1M
NINDS NIH HHS D43 NS118560
6 · The paper itself

Abstract

introductionPost-traumatic seizures (PTS) are common among patients with depressed skull fractures (DSF). Understanding the burden of post traumatic seizures and the factors associated among adult patients with DSF is important to improve clinical care.

objectiveTo determine the prevalence and factors associated with post-traumatic seizures among adult patients with DSF at Mulago National Referral hospital (MNRH).

methodsA cross-sectional study was conducted among 333 study participants between March 2021 and February 2022. Socio-demographic, clinical laboratory factors and anti-seizure medications were collected using a study questionnaire. Data was analysed to determine the prevalence of PTS and factors associated with occurrence of PTS among patients with DSF.

resultsThe mean age (±SD) of study participants was 31.2, (±10.5) years, with a male to female ratio of 10.4:1. Nearly half of the study participants had attained secondary level of education, while 31.6 % (105) were peasants (subsistence farmers). The overall prevalence of PTS among DSF study participants was 16.2 % (54participants). Late presentation of PTS was the highest at 9.0 % (30) followed by early PTS at 3.9 % [13] and immediate PTS at 3.3 % [11]. Moderate Glasgow coma score (GCS: 9-13), p < 0.015, severe traumatic brain injury (GCS: 3-8), p < 0.026 at the time of admission and midline brain shift (≥5mm), p < 0.009 were associated with PTS. Phenytoin (94.3 %) was the most commonly used ASM followed by phenobarbitone (1.4 %) and Valproate (1.1 %) among study participants.

conclusionPatients with moderate and severe traumatic brain injury and midline brain shift were associated with post traumatic seizures. Early identification and intervention may reduce the burden of posttraumatic seizures in this category of patients.

Indexed as

Brain Injuries, TraumaticEpilepsy, Post-TraumaticSkull Fracture, DepressedAdultCross-Sectional StudiesFemaleHospitalsHumansMaleRisk FactorsAnti-seizures medicinesDepressed skull fracturesPost-traumatic seizures

Identifiers

PMID38368722
PMCPMC11027507
OpenAlexW4391906369

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.