ArticleScientific reports2024
Fractal analysis of extracellular matrix for observer-independent quantification of intestinal fibrosis in Crohn's disease.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Understanding and targeting the tumour matrisome.Nature reviews. Clinical oncology · 2026Review
- Classifying the structural heterogeneity of peritoneal adhesions by histopathological extracellular matrix characteristics.Langenbeck's archives of surgery · 2026Article
- Nanoparticle-enabled tuning of cell density for enhanced adhesion and tissue repair.Nature communications · 2026Article
- Quantification and characterization of collagen in experimentally induced wounds treated with different types of platelet-rich plasma gel.Cell and tissue banking · 2026Article
- Evaluation of oral manifestations and mandibular bone fractal dimension in pediatric inflammatory bowel disease.Frontiers in pediatrics · 2026Article
- Collagen architecture in triple negative breast cancer.PloS one · 2025Article
- Role of the serosa in intestinal anastomotic healing: insights from in-depth histological analysis of human and murine anastomoses.BJS open · 2024Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Prevention of intestinal fibrosis remains an unresolved problem in the treatment of Crohn's disease (CD), as specific antifibrotic therapies are not yet available. Appropriate analysis of fibrosis severity is essential for assessing the therapeutic efficacy of potential antifibrotic drugs. The aim of this study was to develop an observer-independent method to quantify intestinal fibrosis in surgical specimens from patients with CD using structural analysis of the extracellular matrix (ECM). We performed fractal analysis in fibrotic and control histological sections of patients with surgery for CD (n = 28). To specifically assess the structure of the collagen matrix, polarized light microscopy was used. A score to quantify collagen fiber alignment and the color of the polarized light was established. Fractal dimension as a measure for the structural complexity correlated significantly with the histological fibrosis score whereas lacunarity as a measure for the compactness of the ECM showed a negative correlation. Polarized light microscopy to visualize the collagen network underlined the structural changes in the ECM network in advanced fibrosis. In conclusion, observer-independent quantification of the structural complexity of the ECM by fractal analysis is a suitable method to quantify the degree of intestinal fibrosis in histological samples from patients with CD.
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