ReviewNature communications2024
Challenges and recent advancements in the synthesis of α,α-disubstituted α-amino acids.
Review in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Direct-inject liquid-chromatography enables an autonomous continuous preferential crystallization platform.Chemical science · 2026Article
- Unlocking congested 3D molecular architectures for drug discovery.Nature chemistry · 2026Article
- Modular diastereoselective synthesis of hindered cyclobutane amino nitriles through triplet nitrene-mediated ring expansion.Nature chemistry · 2026Article
- Palladium-Catalyzed Fluoroallylation of Aldimine Esters With gem-Difluorocyclopropanes: Synthesis of Fluorinated α-Amino Acid Derivatives.Chemistry, an Asian journal · 2026Article
- Catalytically Promiscuous PLP-Dependent Aminotransferases Are Biocatalysts for C-C Bond Formation.ACS central science · 2026Article
- Emerging enzymatic strategies for the synthesis of α-tertiary amino acids.Communications chemistry · 2026Review
- Chemodivergent aminocarbonylation enabled by oxygen vacancy-engineered Pd-doped InScience advances · 2026Article
- α-Alkylated α-amino acids reduce the aggregation of unfolded peptides.RSC advances · 2026Article
- Photo-enabled and thioamide-directed α-C(spNature communications · 2026Article
- Turn-Induction in Peptides Incorporating Novel Cyrene-Derived α,α-Disubstituted Amino Acid.Journal of peptide science : an official publication of the European Peptide Society · 2026Article
- Construction of Phospholipid-Like Vesicles by Aqueous Aminolysis of Acyl Thioesters With Diamino Acids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- EDA Complex-Driven Desaturation of Heterocyclic Carbonyl Compounds Enabled by HFIP.Angewandte Chemie (International ed. in English) · 2025Article
- Synthesis and Evaluation of a Series of Ni(II) Complexed Nucleophilic Glycine Equivalents.ACS omega · 2025Article
- Mechanistic and Structural Analyses of Non-Heme Iron Enzyme TqaM for α-Tertiary Amino Acid Synthesis.Journal of the American Chemical Society · 2025Article
- Electron donor-acceptor complex offers a diverse approach for carbonyl alkylative amination.Chemical science · 2025Article
- Immobilized acyl-transfer molecular reactors enable the solid-phase synthesis of sterically hindered peptides.Nature chemistry · 2025Article
- ARSC advances · 2025Article
- Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications.Chemical reviews · 2025Review
- Asymmetric Intramolecular α-Arylation of Polar Amino Acids Bearing β-Leaving Groups.Angewandte Chemie (International ed. in English) · 2025Article
- Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α,α-Disubstituted α-amino acids (α-AAs) have improved properties compared to other types of amino acids. They serve as modifiers of peptide conformation and as precursors of bioactive compounds. Therefore, it has been a long-standing goal to construct this highly valuable scaffold efficiently in organic synthesis and drug discovery. However, access to α,α-disubstituted α-AAs is highly challenging and largely unexplored due to their steric constraints. To overcome these, remarkable advances have been made in the last decades. Emerging strategies such as synergistic enantioselective catalysis, visible-light-mediated photocatalysis, metal-free methodologies and CO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.