ArticleClinical immunology (Orlando, Fla.)2024
Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia.
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In one paragraph
Article in Clinical immunology (Orlando, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Rebooting immunity in congenital athymia: Factors impacting reconstitution with thymus implantation.Journal of human immunity · 2026Article
- A Novel Variant of CORO1A Gene Contributing to the Development of Primary Immunodeficiency in Children.Case reports in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
57 authors at 20 institutions in 2 countries.
Roshini S AbrahamDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, OH, USA. Electronic address: Roshini.Abraham@nationwidechildrens.org.
Amrita BasuDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, OH, USA.
Jennifer R HeimallDivision of Allergy and Immunology, Children's Hospital of Philadelphia, PA, USA.
Elizabeth DunnDivision of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Alison YipDivision of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Malika KapadiaDivision of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pediatrics, Harvard University Medical School, Boston, MA, USA.
Neena KapoorTransplantation and Cellular Therapy Program, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lisa Forbes SatterPediatrics, Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.
Rebecca BuckleyDepartments of Pediatrics and Immunology, Duke University Medical Center, Durham, NC, USA.
Richard O'ReillyDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Geoffrey D E CuvelierManitoba Blood and Marrow Transplant Program, CancerCare Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Sharat ChandraDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jeffrey BednarskiDivision of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Sonali ChaudhuryDivision of Hematology, Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago-Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Theodore B MooreDivision of Hematology/Oncology, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA.
Hilary HainesDivision of Pediatric Hematology-Oncology and Bone Marrow Transplant, University of Alabama at Birmingham, Birmingham, AL, USA.
Blachy J Dávila SaldañaDivision of Blood and Marrow Transplantation, Children's National Hospital-George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Deepakbabu ChellapandianBlood and Marrow Transplant, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Ahmad RayesDivision of Pediatric Hematology and Oncology, Intermountain Primary Childrens Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA.
Karin ChenDepartment of Pediatrics, University of Washington-Seattle Children's Hospital, Seattle, WA, USA.
Emi CaywoodNemours Children's Health Delaware, Thomas Jefferson University, Wilmington, DE, USA.
Shanmuganathan ChandrakasanBone Marrow Transplantation Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Mark Thomas Vander LugtBlood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI, USA.
Christen EbensDivision of Pediatric Blood and Marrow Transplantation & Cellular Therapy, University of Minnesota, Minneapolis, MN, USA.
Pierre TeiraPediatric Immunology and Rheumatology Division, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
Evan ShereckDivision of Pediatric Hematology/Oncology, Oregon Health and Science University, Portland, OR, USA.
Holly MillerPhoenix Children's Hospital, Phoenix, AZ, USA.
Victor AquinoDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hesham EissaDivision of Pediatric Hematology-Oncology-BMT, University of Colorado, Aurora, CO, USA.
Lolie C YuDivision of Pediatric Hematology-Oncology/HSCT, LSUHSC and Children's Hospital, New Orleans, LA, USA.
Alfred GillioInstitute for Pediatric Cancer and Blood Disorders, Hackensack University Medical Center, Hackensack, NJ, USA.
Lisa MaddenPediatric Blood and Marrow Transplantation Program, Texas Transplant Institute, Methodist Children's Hospital, San Antonio, TX, USA.
Alan KnutsenDepartment of Pediatrics, Pediatric Allergy and Immunology Division, Saint Louis University, St Louis, MO, USA.
Ami J ShahDivision of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine Pediatric Stem Cell Transplantation, Stanford University, Stanford, CA, USA.
Kenneth DeSantesAmerican Family Children's Hospital, University of Wisconsin, Madison, WI, USA.
Jessie BarnumUPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Larisa BroglieDivision of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI, USA.
Avni Y JoshiDivision of Pediatric and Adult Allergy and Immunology, Mayo Clinic, Rochester, MN, USA.
Gary KleinerDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FL, USA.
Jasmeen DaraDivision of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Susan ProckopDivision of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pediatrics, Harvard University Medical School, Boston, MA, USA.
Caridad MartinezPediatrics, Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.
Talal MousallemDepartments of Pediatrics and Immunology, Duke University Medical Center, Durham, NC, USA.
Joseph OvedDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lauri BurroughsDepartment of Pediatrics, University of Washington-Seattle Children's Hospital, Seattle, WA, USA.
Rebecca MarshDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Pharming Healthcare Inc, Warren, NJ, USA.
Troy R TorgersonDepartment of Pediatrics, University of Washington-Seattle Children's Hospital, Seattle, WA, USA.
Jennifer W LeidingDivision of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University Baltimore, MD and Institute for Clinical and Translational Research, Johns Hopkins All Childrens Hospital, St. Petersburg, FL, USA.
Sung Yun PaiImmune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Donald B KohnDepartment of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Michael A PulsipherDivision of Pediatric Hematology and Oncology, Intermountain Primary Childrens Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA.
Linda M GriffithDivision of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Morton J CowanDivision of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Jennifer PuckDivision of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Christopher C DvorakDivision of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Elie HaddadPediatric Immunology and Rheumatology Division, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
University of California, San Francisco · USBaylor College of Medicine · USNational Institutes of Health · USUniversity of Washington · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · USDuke University Hospital · USMemorial Sloan Kettering Cancer Center · USNationwide Children's Hospital · USUniversité de Montréal · CAChildren's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USChildren's Hospital of Pittsburgh · USDuke Medical Center · USGeorge Washington University · USIntermountain Healthcare · USJohns Hopkins All Children's Hospital · USLurie Children's Hospital · USMattel Children's Hospital · USMayo Clinic in Arizona · USOregon Health & Science University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MUTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6MRare Diseases Data Management and Coordinating CenterU01TR001263 · NCATS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2018
$28.1MTraining of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALECH, HARRY · 2009 to 2023
$23.3MData Management and Coordinating Center (DMCC)U54NS064808 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2009 to 2013
$16.5MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MRandomized study of low versus moderate dose busulfan in transplant for severe combined immunodeficiencyU01AI126612 · NIAID · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KEAN, LESLIE S, PULSIPHER, MICHAEL A · 2017 to 2023
$8.5MUnrelated Donor BMT vs. Immune Suppression for Newly Diagnosed Severe Aplastic Anemia in Children and Young Adults: BMT CTN Core Center Renewal for the Pediatric Blood and Marrow Transplant ConsortiumUG1HL069254 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KEAN, LESLIE S · 2017 to 2023
$1.3MPrimary Immune Deficiency Treatment Consortium Annual Scientific MeetingR13AI094943 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2011 to 2025
$239kNCATS NIH HHS U01 TR001263NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA042014NHLBI NIH HHS UG1 HL069254NIAID NIH HHS R13 AI094943NIAID NIH HHS U01 AI126612NIAID NIH HHS U54 AI082973NINDS NIH HHS U54 NS064808
Abstract
Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there was a higher proliferative response with the PHA flow assay compared to the
Indexed as
LymphopeniaSevere Combined ImmunodeficiencyCell ProliferationHumansInfant, NewbornNeonatal ScreeningT-LymphocytesMitogenPHAPIDTCSCIDSevere combined immunodeficiencyT-cell lymphopeniaT-cell proliferation
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