Evidence map›Paper›PMID 38367666›Full record

ArticleThe Journal of biological chemistry2024

E3 ubiquitin ligase rififylin has yin and yang effects on rabbit cardiac transient outward potassium currents (I

Anatoli Y Kabakov, Karim Roder, Peter Bronk, Nilüfer N Turan, Saroj Dhakal, Mingwang Zhong, Yichun Lu, Zachary A Zeltzer, Yonatan B Najman-Licht, Alain Karma and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Anatoli Y KabakovDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Karim RoderDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Peter BronkDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Nilüfer N TuranDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Saroj DhakalPhysics Department and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts, USA.
Mingwang ZhongPhysics Department and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts, USA.
Yichun LuDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Zachary A ZeltzerDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Yonatan B Najman-LichtDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Alain KarmaPhysics Department and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts, USA.
Gideon KorenDivision of Cardiology, Department of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA. Electronic address: gideon_koren@brown.edu.
Brown University · USRhode Island Hospital · USNortheastern University · US

Funding

A Multi-Scale Approach to Cardiac Arrhythmia: from the Molecule to the OrganR01HL110791 · NHLBI · RHODE ISLAND HOSPITAL · PI KOREN, GIDEON · 2013 to 2017
$7.3M
Scarring and Arrhythmia in Infarcted Aged Hearts: Role of Senescent FibroblastsR01HL139467 · NHLBI · RHODE ISLAND HOSPITAL · PI KOREN, GIDEON, SEDIVY, JOHN M · 2019 to 2022
$4.1M
Cardiac ubiquitin ligases: regulation and role in modulating cardiac excitation.R01HL134706 · NHLBI · RHODE ISLAND HOSPITAL · PI KOREN, GIDEON · 2017 to 2020
$2.4M
NHLBI NIH HHS R01 HL110791NHLBI NIH HHS R01 HL134706NHLBI NIH HHS R01 HL139467
6 · The paper itself

Abstract

Genome-wide association studies have reported a correlation between a SNP of the RING finger E3 ubiquitin protein ligase rififylin (RFFL) and QT interval variability in humans (Newton-Cheh et al., 2009). Previously, we have shown that RFFL downregulates expression and function of the human-like ether-a-go-go-related gene potassium channel and corresponding rapidly activating delayed rectifier potassium current (I

Indexed as

Myocytes, CardiacShal Potassium ChannelsUbiquitin-Protein LigasesAction PotentialsAnimalsGenome-Wide Association StudyHEK293 CellsHumansPotassiumRabbitsPotassiumShal Potassium ChannelsUbiquitin-Protein Ligasesaction potential durationcardiomyocyteKChIP2Kv1.4Kv4.3potassium channelRFFLubiquitin ligase

Identifiers

PMID38367666
PMCPMC10945274
OpenAlexW4391850866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.