Evidence map›Paper›PMID 38367632›Full record

ReviewThe lancet. Gastroenterology & hepatology2024

Under-representation of the WHO African region in clinical trials of interventions against hepatitis B virus infection.

Marion Delphin, Khadija Said Mohammed, Louise O Downs, Sheila F Lumley, Elizabeth Waddilove, Dorcas Okanda, Nadia Aliyan, Marije Van Schalkwyk, Motswedi Anderson, Ponsiano Ocama and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The lancet. Gastroenterology & hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Marion DelphinThe Francis Crick Institute, London, UK.
Khadija Said MohammedThe Francis Crick Institute, London, UK; Division of Biosciences, Faculty of Life Sciences, University College London, London, UK.
Louise O DownsNuffield Department of Medicine, University of Oxford, Oxford, UK; Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford, UK; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Sheila F LumleyNuffield Department of Medicine, University of Oxford, Oxford, UK; Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford, UK.
Elizabeth WaddiloveThe Francis Crick Institute, London, UK.
Dorcas OkandaKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Nadia AliyanKilifi County Hospital, Kilifi, Kenya.
Marije Van SchalkwykDivision of Infectious Diseases, Department of Medicine, Stellenbosch University-Tygerberg Academic Hospital, Cape Town, South Africa.
Motswedi AndersonThe Francis Crick Institute, London, UK; Botswana Harvard AIDS Institute Partnership, Princess Marina Hospital, Gaborone, Botswana; Africa Health Research Institute, Durban, South Africa.
Ponsiano OcamaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Tongai MapongaDivision of Medical Virology, Stellenbosch University-National Health Laboratory Service Tygerberg Business Unit, Cape Town, South Africa.
Judith TorimiroMolecular Biology Laboratory, Chantal Biya International Reference Centre for AIDS Research, Yaounde, Cameroon.
Collins IwujiAfrica Health Research Institute, Durban, South Africa; Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
Thumbi Ndung'uDivision of Infection and Immunity, University College London, London, UK; Africa Health Research Institute, Durban, South Africa.
Philippa C MatthewsThe Francis Crick Institute, London, UK; Division of Infection and Immunity, University College London, London, UK; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Department of Infectious Diseases, University College London Hospital, London, London, UK. Electronic address: philippa.matthews@crick.ac.uk.
Jantjie TaljaardDivision of Infectious Diseases, Department of Medicine, Stellenbosch University-Tygerberg Academic Hospital, Cape Town, South Africa.

Funding

Wellcome Trust 110110Wellcome Trust CC2223
6 · The paper itself

Abstract

The WHO African region bears a disproportionate burden of morbidity and mortality related to chronic hepatitis B virus (HBV) infection and accounts for an estimated 70% of new HBV infections worldwide. We investigated the extent to which HBV clinical trials represented populations in this region by searching the WHO International Clinical Trials Registry Platform and ClinicalTrials.gov for interventional clinical trials published in English between database inception and May 29, 2023, using the search term "Hepatitis B". We identified 1804 unique clinical trials, of which 18 (1·0%) recorded involvement of the WHO African region. There is no evidence that the number of HBV clinical trials in this region has improved over time. The diversity of new interventions and industry sponsorship in the WHO African region were low, with trials of HBV comparing poorly with those of other endemic infectious diseases (eg, malaria, HIV, and SARS-CoV-2). HBV research and clinical trial investigations have neglected the WHO African region, leading to profound health inequities. HBV clinical trials are urgently needed to evaluate the efficacy of newly discovered therapeutics and to ensure that interventions can be equitably distributed and deployed as they become available.

Indexed as

Hepatitis BHepatitis B, ChronicHepatitis B virusHumansWorld Health Organization

Identifiers

PMID38367632
PMCPMC7616036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.