Evidence map›Paper›PMID 38367619›Full record

ArticleAmerican journal of human genetics2024

Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts.

Brian Z Huang, Alexandra M Binder, Brandon Quon, Yesha M Patel, Annette Lum-Jones, Maarit Tiirikainen, Sharon E Murphy, Lenora Loo, Alika K Maunakea, Christopher A Haiman and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Brian Z HuangDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA. Electronic address: brian.huang@usc.edu.
Alexandra M BinderPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Brandon QuonPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Yesha M PatelDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Annette Lum-JonesPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Maarit TiirikainenPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Sharon E MurphyMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Lenora LooPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Alika K MaunakeaDepartment of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Christopher A HaimanDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Lynne R WilkensPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Woon-Puay KohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Melinda C AldrichDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Kimberly D SiegmundDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Jian-Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Daniel O StramDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Loïc Le MarchandPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Sungshim L ParkPopulation Sciences of the Pacific Program-Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA. Electronic address: lpark@cc.hawaii.edu.
University of Hawaiʻi at Mānoa · USKeck Hospital of USC · USVanderbilt University Medical Center · USUniversity of Minnesota Medical Center · USNational University of Singapore · SGUniversity of Pittsburgh · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of SmokersP01CA138338 · NCI · UNIVERSITY OF MINNESOTA · PI Daniel O Stram · 2010 to 2026
$33.4M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
Cancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3M
Biomarkers of NNK in prediction of lung cancer development in smokersR01CA129534 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2009 to 2013
$2.8M
Multidisciplinary Training in Ethnic Diversity and Cancer DisparitiesT32CA229110 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2019 to 2023
$2.1M
Integrating epidemiologic, clinical, genomic and metabolomic profiles to predict pancreatic cancer risk in a multiethnic populationR00CA256525 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HUANG, BRIAN · 2023 to 2025
$747k
Integrating epidemiologic, clinical, genomic and metabolomic profiles to predict pancreatic cancer risk in a multiethnic populationK99CA256525 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HUANG, BRIAN · 2021 to 2022
$240k
NCI NIH HHS K99 CA256525NCI NIH HHS P01 CA138338NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA071789NCI NIH HHS R00 CA256525NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA129534NCI NIH HHS R01 CA144034NCI NIH HHS T32 CA229110NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA202979NCI NIH HHS UM1 CA182876
6 · The paper itself

Abstract

The impact of tobacco exposure on health varies by race and ethnicity and is closely tied to internal nicotine dose, a marker of carcinogen uptake. DNA methylation is strongly responsive to smoking status and may mediate health effects, but study of associations with internal dose is limited. We performed a blood leukocyte epigenome-wide association study (EWAS) of urinary total nicotine equivalents (TNEs; a measure of nicotine uptake) and DNA methylation measured using the MethylationEPIC v1.0 BeadChip (EPIC) in six racial and ethnic groups across three cohort studies. In the Multiethnic Cohort Study (discovery, n = 1994), TNEs were associated with differential methylation at 408 CpG sites across >250 genomic regions (p < 9 × 10

Indexed as

MicroRNAsSmokersCohort StudiesCpG IslandsDNA MethylationEpigenesis, GeneticEpigenomeGenome-Wide Association StudyHumansNicotineProspective StudiesReceptors, G-Protein-CoupledReceptors, PeptideGPR15 protein, humanMicroRNAsMIRN383 microRNA, humanNicotineReceptors, G-Protein-CoupledReceptors, PeptidecohortDNA methylationepigeneticsepigenome-wide association studyEWASlung cancernicotinerace and ethnicitysmokingtotal nicotine equivalents

Identifiers

PMID38367619
PMCPMC10940014
OpenAlexW4391887938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.