Evidence map›Paper›PMID 38367238›Full record

ArticleCell reports2024

The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.

Milton Pereira, Theresa Ramalho, Warrison A Andrade, Danielle F Durso, Maria C Souza, Katherine A Fitzgerald, Douglas T Golenbock, Neal Silverman, Ricardo T Gazzinelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. The role of IRF5 as an immune regulator.Biochemical Society transactions · 2026
    Review
  2. Article
  3. Article
  4. Cysteine-S-nitrosylation inhibits Rop5-mediated immune evasion inbioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Milton PereiraDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: milton.pereira@umassmed.edu.
Theresa RamalhoDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Warrison A AndradeDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Danielle F DursoDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Maria C SouzaDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Katherine A FitzgeraldDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Douglas T GolenbockDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Neal SilvermanDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Ricardo T GazzinelliDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Centro de Tecnologia de Vacinas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil. Electronic address: ricardo.gazzinelli@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

Sugar-feeding behavior of the malaria vector Nyssorhynchus darlingi and development of effective attractive toxic sugar baits (ATSB) to increase intervention success in PeruU19AI089681 · NIAID · YALE UNIVERSITY · PI FERREIRA, MARCELO URBANO · 2010 to 2023
$20.1M
Innate Immune Activation in MalariaR01AI079293 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., GOLENBOCK, DOUGLAS T · 2009 to 2024
$10.9M
From Drosophila Immunity to Anti-InflammatoriesR01AI060025 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Neal Silverman · 2004 to 2026
$9.4M
Gene Regulation in Innate ImmunityR37AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2015 to 2024
$4.6M
Innate Immune Receptors for Toxoplasma gondiiR01AI071319 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAZZINELLI, RICARDO TOSTES · 2006 to 2010
$2.7M
Monocyte-derived dendritic cells in malariaR01NS098747 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAZZINELLI, RICARDO TOSTES, LUSTER, ANDREW D · 2016 to 2020
$2.1M
NIAID NIH HHS R01 AI060025NIAID NIH HHS R01 AI071319NIAID NIH HHS R01 AI079293NIAID NIH HHS R37 AI067497NIAID NIH HHS U19 AI089681NINDS NIH HHS R01 NS098747
6 · The paper itself

Abstract

Activation of endosomal Toll-like receptor (TLR) 7, TLR9, and TLR11/12 is a key event in the resistance against the parasite Toxoplasma gondii. Endosomal TLR engagement leads to expression of interleukin (IL)-12 via the myddosome, a protein complex containing MyD88 and IL-1 receptor-associated kinase (IRAK) 4 in addition to IRAK1 or IRAK2. In murine macrophages, IRAK2 is essential for IL-12 production via endosomal TLRs but, surprisingly, Irak2

Indexed as

Interleukin-1 Receptor-Associated KinasesToxoplasmosisAnimalsDendritic CellsInterferon Regulatory FactorsInterleukin-12MiceInterferon Regulatory FactorsInterleukin-12Interleukin-1 Receptor-Associated KinasesIrak1 protein, mouseIrf5 protein, mousecell signalingCP: ImmunologyCP: Microbiologydendritic cellsIL-12innate immunityIRAKIRF5monocytesmyddosomeToll-like receptorsToxoplasma gondii

Identifiers

PMID38367238
PMCPMC11559090
OpenAlexW4394758845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.