Evidence map›Paper›PMID 38367207›Full record

Trial reportAging clinical and experimental research2024

Prefrontal cortex activation while walking did not change but gait speed improved after a randomized physical therapy intervention.

Andrea L Rosso, Emma M Baillargeon, Subashan Perera, Jessie VanSwearingen, Caterina Rosano, Theodore J Huppert, Jennifer S Brach

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea L RossoDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. alr143@pitt.edu.
Emma M BaillargeonDivision of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Subashan PereraDivision of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jessie VanSwearingenDepartment of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA.
Caterina RosanoDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Theodore J HuppertDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Jennifer S BrachDepartment of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Task Specific Timing and Coordination Exercises to Improve Mobility in Older AdultsR01AG045252 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRACH, JENNIFER S · 2015 to 2019
$2.7M
Restoring Central Motor Control to Improve Community Mobility of Older AdultsR01AG057671 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSSO, ANDREA L · 2018 to 2021
$2.5M
MIDCAREER INVESTIGATOR AWARD IN TRANSLATIONAL PATIENT-ORIENTED RESEARCH IN AGINGK24AG057728 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRACH, JENNIFER S · 2018 to 2022
$658k
Environmental Challenges and the Aging Brain: Implications for Community MobilityK01AG053431 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSSO, ANDREA L · 2016 to 2020
$509k
NIA NIH HHS K01 AG053431NIA NIH HHS K24 AG057728NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG045252NIA NIH HHS R01 AG045252ANIA NIH HHS R01 AG057671
6 · The paper itself

Abstract

backgroundHigher prefrontal cortex (PFC) activation while walking may indicate reduced gait automaticity.

aimWe examine whether PFC activation during walking improves after training in older adults at risk for mobility disability.

methodsForty-two adults aged ≥ 65 participated in a randomized clinical trial (NCT026637780) of a 12-week timing and coordination physical therapy intervention to improve walking (n = 20 intervention, n = 22 active control). PFC activation was measured by functional near-infrared spectroscopy (fNIRS) during four walking tasks over 15 m, each repeated 4 times: even surface walking, uneven surface walking, even dual-task, uneven dual-task; dual-task was reciting every other letter of the alphabet while walking. Gait speed and rate of correct letter generation were recorded. Linear mixed models tested between arm differences in change of fNIRS, gait speed, and letter generation from baseline to follow-up (12-week, 24-week, and 36-week).

resultsIntervention arms were similar in mean age (74.3 vs. 77.0) and baseline gait speed (0.96 vs. 0.93 m/s). Of 24 comparisons of between arm differences in the fNIRS signals, only two were significant which were not supported by differences at other follow-up times or on other tasks. Gait speed, particularly during dual-task conditions, and correct letter generation did improve post-intervention but improvements did not differ by arm. DISCUSSION AND

conclusionsAfter training, PFC activation during walking generally did not improve and did not differ by intervention arm. Improvements in gait speed without increased PFC activation may point toward more efficient neural control of walking.

Indexed as

Spectroscopy, Near-InfraredWalking SpeedAgedGaitHumansPhysical Therapy ModalitiesPrefrontal CortexWalkingAgingClinical trialDual-taskFunctional near-infrared spectroscopyGaitPhysical therapyPrefrontal cortex

Identifiers

PMID38367207
PMCPMC10874329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.