Evidence map›Paper›PMID 38367091›Full record

SynthesisEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2024

The efficacy and safety of pre-hospital plasma in patients at risk for hemorrhagic shock: an updated systematic review and meta-analysis of randomized controlled trials.

Mohamed Abuelazm, Hazem Rezq, Abdelrahman Mahmoud, Mohammad Tanashat, Abdelrahman Salah, Othman Saleh, Samah Morsi, Basel Abdelazeem

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Pooled it
  2. Blood transfusion strategies for major bleeding in trauma.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Observational
  4. Role of adenosine AEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 3 countries.

Mohamed AbuelazmFaculty of Medicine, Tanta University, Tanta, Egypt.
Hazem RezqFaculty of Medicine, Al-Azhar University, Cairo, Egypt. HazemRezq.2020@azhar.edu.eg.ORCID http://orcid.org/0000-0002-8871-6921
Abdelrahman MahmoudFaculty of Medicine, Minia University, Minia, Egypt.
Mohammad TanashatFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Abdelrahman SalahFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Othman SalehFaculty of Medicine, The Hashemite University, Zarqa, Jordan.
Samah MorsiDepartment of Radiation Oncology, UT Texas MD Anderson, Houston, TX, USA.
Basel AbdelazeemDepartment of Cardiology, West Virginia University, Morgantown, WV, USA.
Al-Azhar University · EGHashemite University · JOMinia University · EGTanta University · EGThe University of Texas MD Anderson Cancer Center · USWest Virginia University · USYarmouk University · JOZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivePlasma is a critical element in hemostatic resuscitation post-injury, and its prompt administration within the prehospital setting may reduce the complications resulting from hemorrhage and shock. Our objective is to assess the efficacy and safety of prehospital plasma infusion in patients susceptible to hemorrhagic shock.

methodsWe conducted our study by aggregating randomized controlled trials (RCTs) sourced from PubMed, EMBASE, Scopus, Web of Science, and Cochrane CENTRAL up to January 29, 2023. Quality assessment was implemented using the Cochrane RoB 2 tool. Our study protocol is registered in PROSPERO under ID: CRD42023397325.

resultsThree RCTs with 760 individuals were included. There was no difference between plasma infusion and standard care groups in 24-h mortality (P = 0.11), 30-day mortality (P = 0.12), and multiple organ failure incidences (P = 0.20). Plasma infusion was significantly better in the total 24-h volume of PRBC units (P = 0.03) and INR on arrival (P = 0.009). For all other secondary outcomes evaluated (total 24-h volume of packed FFP units, total 24-h volume of platelets units, massive transfusion, vasopressor need during the first 24 h, any adverse event, acute lung injury, transfusion reaction, and sepsis), no significant differences were observed between the two groups.

conclusionPlasma infusion in trauma patients at risk of hemorrhagic shock does not significantly affect mortality or the incidence of multiple organ failure. However, it may lead to reduced packed red blood cell transfusions and increased INR at hospital arrival.

Indexed as

Blood Component TransfusionEmergency Medical ServicesPlasmaShock, HemorrhagicHumansRandomized Controlled Trials as TopicResuscitationWounds and InjuriesBleedingMeta-analysisPlasmaShockSystematic reviewTrauma

Identifiers

PMID38367091
PMCPMC11666795
OpenAlexW4391913656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.