Evidence map›Paper›PMID 38367036›Full record

ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2024

The reckoning of chromosomal instability: past, present, future.

Andrew Lynch, Shermineh Bradford, Mark E Burkard

Abstract readReview
PubMed Publisher
In one paragraph

Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Total whole-arm chromosome losses predict malignancy in human cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2024
    Article
  4. KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells.bioRxiv : the preprint server for biology · 2024
    Article
  5. A survey of chromosomal instability measures across mechanistic models.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Two decades of chromosomal instability and aneuploidy.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2024
    Article
  7. A survey of CIN measures across mechanistic models.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andrew LynchUW Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.
Shermineh BradfordUW Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.
Mark E BurkardUW Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. mburkard@wisc.edu.
University of Wisconsin Carbone Cancer Center · USUniversity of Wisconsin–Madison · US

Funding

Training in Cancer Biology Training GrantT32CA009135 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1985 to 2024
$10.4M
Impact of chromosomal instability on sensitivity to microtubule-targeting drugs in breast cancerR01CA234904 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E, WEAVER, BETH A · 2019 to 2023
$2.7M
Mechanisms of Plk1 at the mitotic centromereR01GM141068 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WEAVER, BETH A · 2021 to 2024
$1.2M
Frequency and consequences of chromosome missegregation in breast cancerF31CA254247 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LYNCH, ANDREW · 2021 to 2022
$67k
NCI NIH HHS F31 CA254247NIH HHS 1R01CA234904NIH HHS F31CA254247NIH HHS T32CA009135
6 · The paper itself

Abstract

Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we review measures of CIN through its rise as a field, discuss considerations for its measurement, and look forward to future quantification of CIN.

Indexed as

AneuploidyNeoplasmsChromosomal InstabilityHumansAneuploidyCancerCINCytogeneticsGenomic instabilityQuantitative measures

Identifiers

PMID38367036
OpenAlexW4391897699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.