ArticleSystematic biology2024
Clockor2: Inferring Global and Local Strict Molecular Clocks Using Root-to-Tip Regression.
Article in Systematic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Three thousand five hundred years of sheeppox virus evolution inferred from archaeological and codicological genomes.Science advances · 2026Article
- One Health genomic surveillance reveals structured urban rabies transmission and major surveillance gaps.bioRxiv : the preprint server for biology · 2026Article
- The Phylodynamic Threshold of Measurably Evolving Populations.Molecular biology and evolution · 2026Article
- Molecular characterization and phylogeography of equine influenza virus H3N8 detected in donkeys in Nigeria 2022-2023.BMC veterinary research · 2026Article
- Genomic and ecological systems-thinking framework for pathogenicFrontiers in public health · 2026Article
- The rise and spread of invasiveMicrobial genomics · 2026Article
- Extensive Endemic Transmission of Multidrug-ResistantOpen forum infectious diseases · 2026Article
- Reliable estimates of Japanese encephalitis virus evolutionary rate supported by a formal test of temporal signal.Molecular genetics and genomics : MGG · 2025Article
- Structural and phenotypic plasticity of the RBD loop2 region is a key determinant for HKU5r-CoVs' emergence in mink.bioRxiv : the preprint server for biology · 2025Article
- Distinct Evolutionary Signatures of Human Parainfluenza Viruses 2 and 4 Reveal Host Antagonism Divergence and Phylogenetic Discordance.Molecular biology and evolution · 2025Article
- Phylogenomics and structural modelling feature accelerated evolution of Oropouche virus: 1955 to 2024.Virologica Sinica · 2025Article
- The Re-emergence of Chikungunya in Sri Lanka: A Genomic investigation.medRxiv : the preprint server for health sciences · 2025Article
- Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus.PLoS pathogens · 2024Article
- Assessing the effect of model specification and prior sensitivity on Bayesian tests of temporal signal.PLoS computational biology · 2024Article
- Time-calibrated phylogenetic and chromosomal mobilome analyses of Staphylococcus aureus CC398 reveal geographical and host-related evolution.Nature communications · 2024Article
- PhyloJS: Bridging phylogenetics and web development with a JavaScript utility library.Ecology and evolution · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Molecular sequence data from rapidly evolving organisms are often sampled at different points in time. Sampling times can then be used for molecular clock calibration. The root-to-tip (RTT) regression is an essential tool to assess the degree to which the data behave in a clock-like fashion. Here, we introduce Clockor2, a client-side web application for conducting RTT regression. Clockor2 allows users to quickly fit local and global molecular clocks, thus handling the increasing complexity of genomic datasets that sample beyond the assumption of homogeneous host populations. Clockor2 is efficient, handling trees of up to the order of 104 tips, with significant speed increases compared with other RTT regression applications. Although clockor2 is written as a web application, all data processing happens on the client-side, meaning that data never leave the user's computer. Clockor2 is freely available at https://clockor2.github.io/.
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