Evidence map›Paper›PMID 38366810›Full record

Trial reportActa obstetricia et gynecologica Scandinavica2024

Childbirth experiences in women with polycystic ovary syndrome: A cohort study.

Anne Engtrø Husby, Melanie Rae Simpson, Rebecka Dalbye, Marit Larsen, Eszter Vanky, Tone Shetelig Løvvik

2 registry-linked trialsOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta obstetricia et gynecologica Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01587378 nacompletednot on this map

A Prospective, Randomized, Double-blind, Multi-centre Study, Where the Possible Effect of Metformin to Prevent Late Miscarriage and Preterm Delivery is Studied in Women With Polycystic Ovary Syndrome (PCOS)

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2012 to 2017Enrolled489ConditionsPregnancy, Polycystic Ovary SyndromeArmsMetformin, placebo
NCT02221427 naunknown statusnot on this map

The Labour Progression Study, a Cluster Randomised Trial on Labour Progression for First Time Mothers

TypeinterventionalSponsorOstfold Hospital TrustRan2014 to 2025Enrolled6,582ConditionsCaesarean Sections, Augmentation With Oxytocin, Labour DystociaArmsDynamic progression curve, Static labour progression curve (F)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Childbirth experiences in women with polycystic ovary syndrome: A cohort study.Acta obstetricia et gynecologica Scandinavica · 2024
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anne Engtrø HusbyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0001-9541-158X
Melanie Rae SimpsonDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Rebecka DalbyeDepartment of Obstetrics and Gynecology, Østfold Hospital Trust, Grålum, Norway.
Marit LarsenDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0009-0003-3885-2532
Eszter VankyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Tone Shetelig LøvvikDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Norwegian University of Science and Technology · NOOsloMet – Oslo Metropolitan University · NO

Funding

Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige UniversitetNovo Nordisk FondenResearch Council NorwaySt. Olavs Hospital Universitetssykehuset i TrondheimSykehuset ØstfoldThe Liaison committee between the Central Norway Health Authorities and the universities and colleges in Central Norway
6 · The paper itself

Abstract

introductionWomen with polycystic ovary syndrome (PCOS) have more pregnancy complications like gestational diabetes, hypertension, and preterm labor than other women. Metformin has been used in an attempt to improve pregnancy outcomes. Our study aims to explore childbirth experiences in women with PCOS compared with a reference population. It also explores the potential influence of metformin, obesity, pregnancy complications, and the duration and mode of birth on childbirth experiences. MATERIAL AND

methodsThis study is a cohort study combining data from two randomized trials conducted in Norway, Sweden and Iceland. The PregMet2 study (ClinicalTrials.gov, NCT01587378) investigated the use of metformin vs. placebo in pregnant women with PCOS. The Labour Progression Study (ClinicalTrials.gov, NCT02221427) compared the WHO partograph to Zhang's guidelines for progression of labor and were used as the reference population. A total of 365 women with PCOS and 3604 reference women were included. Both studies used the Childbirth Experience Questionnaire (CEQ). Main outcome measures were total CEQ score and four domain scores. The CEQ scores were compared using Mann-Whitney U test for women in Robson group 1 with PCOS (n = 131) and reference women (n = 3604). CEQ scores were also compared between metformin-treated (n = 180) and placebo-treated (n = 185) women with PCOS, and for different subgroups of women with PCOS.

resultsThere was no difference in total CEQ score between women with PCOS and reference women-Wilcoxon-Mann-Whitney (WMW)-odds 0.96 (95% confidence interval [CI] 0.78-1.17). We detected no difference in CEQ scores between the metformin- and placebo-treated women with PCOS (WMW-odds 1.13, 95% CI 0.89-1.43). Complications in pregnancy did not affect CEQ (WMW-odds 1, 95% CI 0.76-1.31). Higher body mass index (WMW-odds 0.75, 95% CI 0.58-0.96), longer duration of labor (WMW-odds 0.69, 95% CI 0.49-0.96), and cesarean section (WMW-odds 0.29, 95% CI 0.2-0.42) were associated with lower CEQ scores in women with PCOS.

conclusionsWomen with PCOS experience childbirth similarly to the reference women. Metformin did not influence childbirth experience in women with PCOS, neither did pregnancy complications. Obesity, long duration of labor or cesarean section had a negative impact on childbirth experience.

Indexed as

MetforminPolycystic Ovary SyndromeAdultCohort StudiesFemaleHumansHypoglycemic AgentsIcelandNorwayParturitionPregnancyPregnancy ComplicationsSurveys and QuestionnairesSwedenHypoglycemic AgentsMetforminChildbirth Experience Questionnairechildbirth experiencespolycystic ovary syndrome

Identifiers

PMID38366810
PMCPMC11103144
OpenAlexW4391897489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.