ReviewAesthetic surgery journal2024
A Structured Approach for Treating Calcium Hydroxylapatite Focal Accumulations.
Review in Aesthetic surgery journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatite (CaHA) in the Face: A Systematic Review.Aesthetic plastic surgery · 2026Pooled it
- A Comparative Study of the Efficacy of Different Tissue Fillers for Nasolabial Fold Correction.Aesthetic plastic surgery · 2026Pooled it
- First Insights on the Upcoming Role of Next-Generation PLLA-LASYNPRO in Aesthetic and Regenerative Medicine: A Survey of Experts-the PLLA-LASYNPRO Rationale.Facial plastic surgery : FPS · 2026Article
- Article
- When Labiaplasty is Not Enough: Rejuvenation of the Labia Majora Using Hybrid Calcium Hydroxylapatite With Hyaluronic Acid Filler for Increased Satisfaction and Uniform Results.Aesthetic surgery journal. Open forum · 2026Article
- Evaluation of Safety and Efficacy of Polycaprolactone-Based Fillers Combined with Glucocorticoid in Dermal Fillers: A Preclinical Investigation.Aesthetic plastic surgery · 2025Article
- Complications of Calcium Hydroxyapatite in Lower Eyelid Rejuvenation: Case Report of Granuloma Formation.Plastic and reconstructive surgery. Global open · 2025Article
- Prevention of Calcium Hydroxyapatite Nodules in the Neck With Use of Botulinum Toxin: A Case Report and Review of Anatomy and Pathophysiology.Journal of cosmetic dermatology · 2025Review
- Reduction of Early-Onset Calcium Hydroxylapatite-Carboxymethylcellulose Accumulations Using Focused Mechanical Vibration: An Experimental Model and Case Report.Journal of cosmetic dermatology · 2025Article
- Essential Pharmaceutical Drugs in the Filler Emergency Kit.Aesthetic plastic surgery · 2025Review
- Clinical Management of Poly-D,L-Lactic Acid Nodules: A Guideline With Diagnostic and Treatment Flowchart.Journal of cosmetic dermatology · 2025Article
- Modulating rheology and bioactivity in dermal fillers: the emerging role of platelet-rich plasma (PRP).Frontiers in medicine · 2025Review
- Prevention and Management of Complications With a Hyaluronic Acid-Calcium Hydroxyapatite Hybrid Injectable.Clinical, cosmetic and investigational dermatology · 2025Review
- Successful Treatment of Noninflammatory CaHA Nodules Using Focused Mechanical Vibration.Aesthetic surgery journal. Open forum · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiesse, a widely utilized calcium hydroxylapatite (CaHA) dermal filler, has shown effectiveness in soft tissue augmentation and regeneration. As with all dermal fillers, the potential for nodules may arise. Understanding the pathogenesis of these nodules and exploring effective treatment methodologies are crucial for optimizing patient outcomes.
objectivesA literature search was carried out to identify published literature documenting reversal of CaHA nodules. After identification, a consensus panel developed a structured approach, denoted by levels, for applying such reversal methods.
methodsThis concise review presents an algorithmic approach to addressing CaHA focal accumulations (noninflammatory nodules) based on invasiveness, cost, and potential risks based on published literature.
resultsLevel 0 involves no intervention, relying on natural degradation for asymptomatic nodules. Level 1 interventions utilize mechanical dispersion techniques, including massage and in situ dispersion, which have demonstrated high success rates, cost effectiveness, and minimal invasiveness. Level 2 introduces alternative modalities such as pharmacological treatments with 5-fluorouracil and corticosteroids, lasers, and experimental approaches. Level 3 represents last-resort options, including calcium-chelating agents, manual removal, and surgical excision.
conclusionsThe article offers a structured approach to managing CaHA focal accumulations. LEVEL OF EVIDENCE: 4:
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.