Evidence map›Paper›PMID 38366732›Full record

ArticleAIDS research and human retroviruses2024

Active Tuberculosis Is Associated with Depletion of HIV-Specific CD4 and CD8 T Cells in People with HIV.

Jeremiah Khayumbi, Loren E Sasser, Taryn A McLaughlin, Benson Muchiri, Joshua Ongalo, Joan Tonui, Samuel Gurrion Ouma, Angie Campbell, Felix Hayara Odhiambo, Chelimo Kiprotich and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jeremiah KhayumbiCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Loren E SasserDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Taryn A McLaughlinDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Benson MuchiriCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Joshua OngaloCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Joan TonuiCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Samuel Gurrion OumaCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Angie CampbellDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Felix Hayara OdhiamboCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Chelimo KiprotichDepartment of Biomedical Sciences, School of Public Health and Community Development, Maseno University, Kisumu, Kenya.
Neel R GandhiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Cheryl L DayDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · USKenya Medical Research Institute · KEMaseno University · KE

Funding

Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI KLEIN, ROBERT STEPHEN · 2003 to 2013
$18.6M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
NK cell-mediated regulation of T cell immunity in TB/HIV co-infectionR01AI111948 · NIAID · EMORY UNIVERSITY · PI DAY, CHERYL LIANE · 2014 to 2018
$3.7M
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
NIAID NIH HHS K24 AI114444NIAID NIH HHS P30 AI051519NIAID NIH HHS P30 AI168386NIAID NIH HHS R01 AI111948
6 · The paper itself

Abstract

Infection with

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHIV InfectionsMycobacterium tuberculosisTuberculosisAdultCohort StudiesCoinfectionFemaleFlow CytometryGranzymesHLA-DR AntigensHumansKenyaKi-67 AntigenLatent TuberculosisGranzymesHLA-DR AntigensKi-67 AntigenPerforinCD4 T cellCD8 T cellHIVimmune activationMycobacterium tuberculosistuberculosis

Identifiers

PMID38366732
PMCPMC11295841
OpenAlexW4391914909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.