Evidence map›Paper›PMID 38366593›Full record

ArticleCell2024

Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis.

Baiyu Qiu, Fereshteh Zandkarimi, Carla T Bezjian, Eduard Reznik, Rajesh Kumar Soni, Wei Gu, Xuejun Jiang, Brent R Stockwell

Open access · greenAbstract read
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 2 pooled it
129.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 2 syntheses or guidelines pooled it, 310 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  5. Review
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  8. Review
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  12. Article
  13. Article
  14. Article
  15. Structural and molecular principles of DAMP biology.Nature structural & molecular biology · 2026
    Review
  16. Review
  17. PLA2G2F suppresses ferroptosis through phospholipid remodeling.Nature structural & molecular biology · 2026
    Article
  18. Article
  19. Article
  20. Perilipin-2-Anchored Lipid Droplet-Targeting Phototheranostics.Angewandte Chemie (International ed. in English) · 2026
    Article

157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Baiyu QiuDepartment of Chemistry, Columbia University, New York, NY 10027, USA.
Fereshteh ZandkarimiDepartment of Chemistry, Columbia University, New York, NY 10027, USA; Mass Spectrometry Core Facility, Columbia University, New York, NY 10027, USA.
Carla T BezjianDepartment of Chemistry, Columbia University, New York, NY 10027, USA.
Eduard ReznikDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Rajesh Kumar SoniProteomics and Macromolecular Crystallography Shared Resource, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wei GuInstitute for Cancer Genetics, Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Xuejun JiangCell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Brent R StockwellDepartment of Chemistry, Columbia University, New York, NY 10027, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Pathology and Cell Biology and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: bstockwell@columbia.edu.
Columbia University · USCancer Genetics (United States) · USColumbia University Irving Medical Center · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Defining the functions and translational potential of ferroptosisR35CA209896 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R. · 2016 to 2022
$6.5M
Ferroptosis, Cellular Metabolism, and CancerR01CA204232 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JIANG, XUEJUN · 2017 to 2025
$4.1M
Ferroptosis and Cancer Cell SignalingR01CA258622 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Xuejun Jiang · 2022 to 2026
$2.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204232NCI NIH HHS R01 CA258622NCI NIH HHS R35 CA209896
6 · The paper itself

Abstract

Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA

Indexed as

Dietary FatsFerroptosisPhospholipidsFatty AcidsPhosphatidylcholinesReactive Oxygen SpeciesDietary FatsFatty AcidsPhosphatidylcholinesPhospholipidsReactive Oxygen Speciescomplex Idiacyl-PUFA phosphatidylcholineelectron transport chainferroptosislipidsmitochondriaphospholipidpolyunsaturated fatty acidPUFAROS

Identifiers

PMID38366593
PMCPMC10940216
OpenAlexW4391849363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.