Evidence map›Paper›PMID 38366304›Full record

ArticleInfection2024

Outbreak of severe community-acquired bacterial infections among children in North Rhine-Westphalia (Germany), October to December 2022.

Sarah C Goretzki, Mark van der Linden, Andreas Itzek, Tom Hühne, Roland O Adelmann, Firas Ala Eldin, Mohamed Albarouni, Jan-Claudius Becker, Martin A Berghäuser, Thomas Boesing and 59 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

69 authors at 20 institutions in 1 country.

Sarah C GoretzkiDepartment of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Mark van der LindenGerman Reference Laboratory for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.
Andreas ItzekGerman Reference Laboratory for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.
Tom HühneDepartment of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Roland O AdelmannDepartment of General Pediatrics, Klinikum Oberberg, Kreiskrankenhaus Gummersbach, Gummersbach, Germany.
Firas Ala EldinDepartment of General Pediatrics, Helios Hospital Schwelm, Schwelm, Germany.
Mohamed AlbarouniDepartment of General Pediatrics, Marien-Hospital Gelsenkirchen, Gelsenkirchen, Germany.
Jan-Claudius BeckerDepartment of Pediatrics, Agaplesion Hospital Hagen, Hagen, Germany.
Martin A BerghäuserDivision of Pediatric Intensive Care, Department of Pediatrics, Florence Nightingale Hospital Kaiserswerth, Düsseldorf, Germany.
Thomas BoesingDivision of Pediatric Intensive Care, Department of Pediatrics, Protestant Hospital Bethel, University of Bielefeld, Bielefeld, Germany.
Michael BoeswaldDepartment of Pediatrics, Sankt Franziskus Hospital Münster, Münster, Germany.
Milian BrascheDivision of Neonatology, Department of Pediatrics, University Hospital, RWTH University of Aachen, Aachen, Germany.
Francisco Brevis NuñezDivision of Pediatric Intensive Care, Department of Pediatrics, Sana Hospitals Duisburg, Duisburg, Germany.
Rokya CamaraDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, GFO Hospital Bonn, Bonn, Germany.
Clara DeibertDepartment of General Pediatrics, DRK Hospital Kirchen, Kirchen, Germany.
Frank DohleDepartment of Pediatrics, Pediatric Intensive Care Medicine, St. Vinzenz Hospital Paderborn, Paderborn, Germany.
Jörg DolgnerDepartment of General Pediatrics, GFO Hospital Dinslaken, Dinslaken, Germany.
Jan DziobakaDepartment of Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Frank EifingerDivision of Pediatric Intensive Care, Department of Pediatrics, University Hospital, University of Cologne, Cologne, Germany.
Natalie EltingDepartment of General Pediatrics, Evangelical Hospital Oberhausen, Oberhausen, Germany.
Matthias EndmannDepartment of General Pediatrics, St. Franziskus-Hospital Ahlen, Ahlen, Germany.
Guido EngelmannDepartment of General Pediatrics, Lukas-Hospital Neuss, Neuss, Germany.
Holger FrenzkeDepartment of General Pediatrics, Märkisch Hospital Lüdenscheid, Lüdenscheid, Germany.
Monika GappaDepartment of General Pediatrics, Evangelical Hospital Düsseldorf, Düsseldorf, Germany.
Bahman GharaviDepartment of General Pediatrics, Marien-Hospital Witten, Witten, Germany.
Christine GoletzDepartment of General Pediatrics, Städtische Kliniken Mönchengladbach, Elisabeth-Hospital Rheydt, Mönchengladbach, Germany.
Eva HahnDepartment of Pediatrics and Adolescent Medicine, Sankt Agnes Hospital, Bocholt, Germany.
Yvonne HeidenreichDepartment of General Pediatrics, Hospital Soest gGmbH, Soest, Germany.
Konrad HeimannDivision of Neonatology, Department of Pediatrics, University Hospital, RWTH University of Aachen, Aachen, Germany.
Kai O HenselDivision of Pediatric Intensive Care, Department of Pediatrics, Helios University Hospital Wuppertal, Witten/Herdecke University, Wuppertal, Germany.
Hans-Georg HoffmannDepartment of General Pediatrics, Mathias-Stiftung, Rheine, Germany.
Marc HoppenzDivision of Pediatric Intensive Care, Department of Pediatrics, Children's Hospital, Amsterdamer Str., Cologne, Germany.
Gerd HorneffDepartment of Pediatrics, Asklepios Clinic Sankt Augustin GmbH, Sankt Augustin, Germany.
Helene KlassenDepartment of Pediatrics and Adolescent Medicine, Hochsauerland Hospital, Arnsberg, Germany.
Cordula Koerner-RettbergDepartment of General Pediatrics, Marien-Hospital gGmbH, Wesel, Germany.
Alfred LänglerDepartment of Pediatrics, Gemeinschaftskrankenhaus Herdecke, University of Witten/Herdecke, Herdecke, Germany.
Pascal LenzDepartment of General Pediatrics, Hospital Leverkusen GmbH, Leverkusen, Germany.
Klaus LohmeierDivision of Neonatology and Pediatric Cardiology, Department of General Pediatrics, Heinrich Heine University, Düsseldorf, Germany.
Andreas MüllerDepartment of Neonatology and Pediatric Intensive Care Medicine, University of Bonn, Bonn, Germany.
Frank NiemannDepartment of General Pediatrics, Marien-Hospital Gelsenkirchen, Gelsenkirchen, Germany.
Michael PaulussenDivision of Oncology and Haematology, Department of General Pediatrics, Hospital of Children and Adolescents, University of Witten/Herdecke, Datteln, Germany.
Falk PentekDepartment of Pediatrics, Elisabeth-Hospital Essen, Essen, Germany.
Ruy PerezDivision of Pediatric Intensive Care, Department of Pediatrics, Helios Hospital Krefeld, Krefeld, Germany.
Markus PingelDepartment of General Pediatrics, DRK Hospital Siegen gGmbH, Siegen, Germany.
Philip RepgesDepartment of General Pediatrics, Porz, Cologne, Germany.
Tobias RothoeftDivision of Neonatology and Pediatric Intensive Care, University Children's Hospital, Ruhr University of Bochum, Bochum, Germany.
Jochen RüboDepartment of General Pediatrics, St. Antonius Hospital Kleve, Kleve, Germany.
Herbert SchadeDepartment of General Pediatrics, Hospital Mechernich GmbH, Mechernich, Germany.
Robert SchmitzDepartment of Pediatrics, Helios Clinic Duisburg, Duisburg, Germany.
Peter SchonhoffDepartment of Pediatrics, Clemenshospital Münster, Münster, Germany.
Jan N SchwadeDepartment of General Pediatrics, Evangelical Hospital Lippstadt, Lippstadt, Germany.
Tobias SchwarzDepartment of General Pediatrics, Municipal Hospital Solingen, Solingen, Germany.
Peter SeiffertDepartment of Pediatrics, Helios Clinic Duisburg, Duisburg, Germany.
Georg SelzerDivision of Neonatology and Pediatric Intensive Care, Evangelical Hospital Hamm, Hamm, Germany.
Uwe SpilleDepartment of General Pediatrics, Herford, Germany.
Carsten ThielDepartment of Pediatrics, St.-Clemens-Hospital Geldern, Geldern, Germany.
Ansgar ThimmDepartment of General Pediatrics, Sana-Hospital Remscheid, Remscheid, Germany.
Bartholomäus UrgatzDepartment of General Pediatrics, AKH Hospital Viersen, Viersen, Germany.
Alijda van den HeuvelDivision of Pediatric Intensive Care, Department of Pediatrics, University Hospital Münster, Münster, Germany.
Tan van HopDepartment of General Pediatrics, Hospital Oberhausen Sterkrade gGmbH, Oberhausen, Germany.
Verena GiesenDepartment of General Pediatrics, Bethanien Hospital Moers, Moers, Germany.
Stefan WirthDepartment of Pediatrics, Helios Medical Center Niederberg, Velbert, Germany.
Thomas WollbrinkDivision of Pediatric Intensive Care, Department of Pediatrics, Bergmannsheil Pediatric Hospital Gelsenkirchen Buer, Gelsenkirchen, Germany.
Daniel WüllerDepartment of Pediatrics and Adolescent Medicine, Christophorus Hospital, Coesfeld, Germany.
Ursula Felderhoff-MüserDepartment of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Christian Dohna-SchwakeDepartment of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Thiên-Trí LâmGerman National Reference Laboratory for Meningococci and Haemophilus Influenzae, Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Heike ClausGerman National Reference Laboratory for Meningococci and Haemophilus Influenzae, Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Nora BrunsDepartment of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany. nora.bruns@uk-essen.de.
University of Duisburg-Essen · DERWTH Aachen University · DEMarienhospital Gelsenkirchen · DEBG Klinikum Duisburg · DEClemenshospital Münster · DEEvangelisches Krankenhaus Oberhausen · DESt. Franziskus Hospital · DEWitten/Herdecke University · DEAsklepios Klinik Sankt Augustin · DEChristophorus Kliniken · DEElisabeth-Krankenhaus Essen · DEEvangelisches Krankenhaus Hamm · DEGemeinschaftskrankenhaus Herdecke · DEHamm-Lippstadt University of Applied Sciences · DEHeinrich Heine University Düsseldorf · DEHelios Hospital Schwerin · DEHelios Klinikum Krefeld · DEHerford Hospital · DEInstitute of Medical Microbiology and Hygiene · DEKlinikum Arnsberg · DE

Funding

Robert Koch Institut 1369-235
6 · The paper itself

Abstract

purposeIn late 2022, a surge of severe S. pyogenes infections was reported in several European countries. This study assessed hospitalizations and disease severity of community-acquired bacterial infections with S. pyogenes, S. pneumoniae, N. meningitidis, and H. influenzae among children in North Rhine-Westphalia (NRW), Germany, during the last quarter of 2022 compared to long-term incidences.

methodsHospital cases due to bacterial infections between October and December 2022 were collected in a multicenter study (MC) from 59/62 (95%) children's hospitals in NRW and combined with surveillance data (2016-2023) from the national reference laboratories for streptococci, N. meningitidis, and H. influenzae. Overall and pathogen-specific incidence rates (IR) from January 2016 to March 2023 were estimated via capture-recapture analyses. Expected annual deaths from the studied pathogens were calculated from national death cause statistics.

resultsIn the MC study, 153 cases with high overall disease severity were reported with pneumonia being most common (59%, n = 91). IRs of bacterial infections declined at the beginning of the COVID-19 pandemic and massively surged to unprecedented levels in late 2022 and early 2023 (overall hospitalizations 3.5-fold), with S. pyogenes and S. pneumoniae as main drivers (18-fold and threefold). Observed deaths during the study period exceeded the expected number for the entire year in NRW by far (7 vs. 0.9). DISCUSSION: The unprecedented peak of bacterial infections and deaths in late 2022 and early 2023 was caused mainly by S. pyogenes and S. pneumoniae. Improved precautionary measures are needed to attenuate future outbreaks.

Indexed as

Community-Acquired InfectionsDisease OutbreaksAdolescentBacterial InfectionsChildChild, PreschoolFemaleGermanyHospitalizationHumansIncidenceInfantInfant, NewbornMaleStreptococcus pyogenesBacterial infectionsChildrenCommunity acquired infectionsGermanyOutbreakSurveillance

Identifiers

PMID38366304
PMCPMC11143032
OpenAlexW4391885875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.