Evidence map›Paper›PMID 38366232›Full record

ArticleEuropean heart journal. Acute cardiovascular care2024

Rate of cardiovascular events up to 8 years after uncomplicated myocarditis: a nationwide cohort study.

Andreas Schelldorfer, Claudia Gregoriano, Stephanie Hauser, Tobias A Fuchs, Beat Mueller, Philipp Schuetz, Alexander Kutz

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Acute cardiovascular care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Andreas SchelldorferMedical University Department, Cantonal Hospital Aarau, Tellstrasse 25, CH-5001 Aarau, Switzerland.ORCID 0009-0005-8049-6871
Claudia GregorianoMedical University Department, Cantonal Hospital Aarau, Tellstrasse 25, CH-5001 Aarau, Switzerland.
Stephanie HauserMedical University Department, Cantonal Hospital Aarau, Tellstrasse 25, CH-5001 Aarau, Switzerland.
Tobias A FuchsDepartment of Cardiology, Cantonal Hospital Aarau, Tellstrasse 25, CH-5001 Aarau, Switzerland.
Beat MuellerMedical University Department, Cantonal Hospital Aarau, Tellstrasse 25, CH-5001 Aarau, Switzerland.
Philipp SchuetzMedical University Department, Cantonal Hospital Aarau, Tellstrasse 25, CH-5001 Aarau, Switzerland.
Alexander KutzMedical University Department, Cantonal Hospital Aarau, Tellstrasse 25, CH-5001 Aarau, Switzerland.ORCID 0000-0002-7549-5648
Kantonsspital Aarau · CHUniversity of Basel · CHBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWhile prognosis of acute myocarditis with uncomplicated presentation is perceived as benign, data on long-term outcomes are scarce. We evaluated rates of myocarditis-associated cardiovascular events after a first-time hospitalization with uncomplicated acute myocarditis in patients without known heart disease. METHODS AND

resultsIn this retrospective nationwide population-based cohort study from 2013 to 2020, hospitalized patients with uncomplicated acute myocarditis but without known heart disease were 1:1 propensity score-matched with surgical controls hospitalized for laparoscopic appendectomy. As assessed in time-to-event analyses, the primary outcome was a composite of rehospitalization for myocarditis, pericardial disease, heart failure and its complications, arrhythmias, implantation of cardiac devices, and heart transplant. After matching, we identified 1439 patients with uncomplicated acute myocarditis (median age of 35 years, 74.0% male) and 1439 surgical controls (median age of 36 years, 74.4% male). Over a median follow-up of 39 months, compared with surgical controls, the hazard ratio for the primary composite outcome was 42.3 [95% confidence interval (CI) 17.4-102.8], corresponding to an incidence rate of 43.7 vs. 0.9 per 1000 patient-years (py) and an incidence rate difference of 42.7 (95% CI 36.7-48.8) per 1000 py.

conclusionPatients hospitalized with uncomplicated acute myocarditis and no known prior heart disease were associated with substantial risk for cardiovascular events over a follow-up of up to 8 years. This calls for a more efficient therapeutic management of this population of patients.

Indexed as

MyocarditisAcute DiseaseAdultFemaleFollow-Up StudiesHospitalizationHumansIncidenceMaleMiddle AgedPrognosisPropensity ScoreRetrospective StudiesRisk FactorsTime FactorsAcute myocarditisCardiovascular eventsFollow-upNationwideOutcomes

Identifiers

PMID38366232
PMCPMC11132296
OpenAlexW4391886116

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.