Evidence map›Paper›PMID 38366225›Full record

Trial reportNature nanotechnology2024

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses.

Jack P M Andrews, Shruti S Joshi, Evangelos Tzolos, Maaz B Syed, Hayley Cuthbert, Livia E Crica, Neus Lozano, Emmanuel Okwelogu, Jennifer B Raftis, Lorraine Bruce and 15 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nature nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. HumanBioactive materials · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 3 countries.

Jack P M Andrews *BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Shruti S Joshi *BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9874-6211
Evangelos TzolosBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Maaz B SyedBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Hayley CuthbertThe Royal Infirmary of Edinburgh, Edinburgh, UK.
Livia E CricaNanomedicine Lab, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0002-9665-0862
Neus LozanoCatalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Barcelona, Spain.ORCID 0000-0002-9026-1743
Emmanuel OkweloguNanomedicine Lab, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.
Jennifer B RaftisBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Lorraine BruceBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Craig A PolandCentre for Inflammation Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5345-1249
Rodger DuffinCentre for Inflammation Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-3425-9745
Paul H B FokkensNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
A John F BoereNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Daan L A C LesemanNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Ian L MegsonDivision of Biomedical Sciences, University of the Highlands and Islands, Inverness, UK.ORCID 0000-0001-8287-2459
Phil D WhitfieldDivision of Biomedical Sciences, University of the Highlands and Islands, Inverness, UK.
Kerstin ZieglerDivision of Biomedical Sciences, University of the Highlands and Islands, Inverness, UK.
Seshu TammireddyDivision of Biomedical Sciences, University of the Highlands and Islands, Inverness, UK.
Marilena HadjidemetriouNanomedicine Lab, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.
Cyrill BussyNanomedicine Lab, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0001-8870-443X
Flemming R CasseeNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
David E NewbyBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-7971-4628
Kostas KostarelosNanomedicine Lab, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK. kostas.kostarelos@manchester.ac.uk.ORCID 0000-0002-2224-6672
Mark R MillerBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. mark.miller@ed.ac.uk.ORCID 0000-0002-7078-597X
University of Edinburgh · GBUniversity of Manchester · GBUniversity of the Highlands and Islands · GBNational Institute for Public Health and the Environment · NLCentre for Inflammation Research · GBEdinburgh Royal Infirmary · GBInstitució Catalana de Recerca i Estudis Avançats · ESInstitut Català de Nanociència i Nanotecnologia · ESUtrecht University · NL

Funding

British Heart Foundation CH/09/002/26360British Heart Foundation FS/18/31/33676British Heart Foundation FS/CRTF/20/24087British Heart Foundation RG/16/10/32375British Heart Foundation (BHF) CH/09/002British Heart Foundation (BHF) SP/15/8/31575Wellcome TrustWellcome Trust WT103782AIA
6 · The paper itself

Abstract

Graphene oxide nanomaterials are being developed for wide-ranging applications but are associated with potential safety concerns for human health. We conducted a double-blind randomized controlled study to determine how the inhalation of graphene oxide nanosheets affects acute pulmonary and cardiovascular function. Small and ultrasmall graphene oxide nanosheets at a concentration of 200 μg m

Indexed as

GraphiteNanostructuresAdministration, InhalationAdultBlood PressureDouble-Blind MethodFemaleHeart RateHumansInhalation ExposureMaleParticle SizeYoung Adultgraphene oxideGraphite

Identifiers

PMID38366225
PMCPMC11106005
OpenAlexW4391883418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.