ArticleNature neuroscience2024
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
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Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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44citing papers in PubMed, 2 pooled it
21.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Single-cell RNA sequencing offers novel perspectives in viral infection research.Frontiers in cellular and infection microbiology · 2026Pooled it
- Efficacy and Safety of Pirfenidone for Mitigation of Interstitial Lung Abnormalities in COVID-19 Patients: A Meta-Analysis.Canadian respiratory journal · 2026Pooled it
- Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026Review
- Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS-CoV-2 Infection.MedComm · 2026Article
- Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis.Nature communications · 2026Article
- Cross-Organ Neuroimmunology of Behavior.Annual review of immunology · 2026Review
- Immune-proteo-metabolomic changes link to Aβ and tau pathology in Alzheimer disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neuroinflammation and Oxidative Stress in Parkinson's Disease, Alzheimer's Disease, and COVID-19: Microglia-Neutrophil Interaction.ACS omega · 2026Review
- The Sense of Smell (SoS) Atlas: Its Creation and First Application to Investigate COVID-19 Related Anosmia With a Comprehensive Quantitative MRI Protocol.Journal of magnetic resonance imaging : JMRI · 2026Article
- Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Roles of Reactive Oxygen Species in Relationships Between Viral Infections and Alzheimer's Disease and Related Dementia.Antioxidants (Basel, Switzerland) · 2026Review
- Unraveling the cardiovascular burden of long COVID: symptom profiles, underlying mechanisms, and clinical management insights.Frontiers in cardiovascular medicine · 2026Review
- SARS-CoV-2-induced damage to rat cortical neuronal networks ex vivo is mediated by the pro-inflammatory activation of the cGAS-STING pathway.Journal of neurovirology · 2025Article
- ApoE4 Homozygosity Is Associated With Increased Microglia Activation in Fatal COVID-19.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025Article
- Impact of COVID-19 pandemic on cognitive decline in community-dwelling older adults in Shanghai: a longitudinal study from 2010 to 2024.The Lancet regional health. Western Pacific · 2025Article
- The impact of acute COVID-19 symptoms on insomnia: A longitudinal study among medical students.Brain, behavior, & immunity - health · 2025Article
- Cerebral microstructural alterations as an imaging biomarker for Post-COVID-condition.Scientific reports · 2025Article
- Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025Review
- Spatial Transcriptomics to Study Virus-Host Interactions.Annual review of virology · 2025Review
- Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem.Nature communications · 2025Article
Corrections and comments
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Authors and funding
50 authors at 12 institutions in 1 country.
Josefine Radke *Institute of Pathology, Universitätsmedizin Greifswald, Greifswald, Germany. josefine.radke@med.uni-greifswald.de.ORCID http://orcid.org/0000-0001-9860-2007
Jenny Meinhardt *Department of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-0366-2416
Tom Aschman *Department of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-2101-6146
Robert Lorenz Chua *Center of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Vadim Farztdinov *Core Facility High Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Sören LukassenCenter of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-7045-6327
Foo Wei TenCenter of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Ekaterina FriebelDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-1419-2376
Naveed IshaqueCenter of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-8426-901X
Jonas FranzDepartment of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-7523-6622
Valerie Helena HuhleDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Ronja MothesDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Kristin PetersInstitute of Pathology, Universitätsmedizin Greifswald, Greifswald, Germany.
Carolina ThomasDepartment of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-7386-1181
Shirin SchneebergerDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Elisa SchumannDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Leona KawelkeDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Julia JüngerDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Viktor HorstDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Simon StreitDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Regina von ManitiusDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Péter KörtvélyessyDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Stefan VielhaberDepartment of Neurology, Otto von Guerike University Magdeburg, Magdeburg, Germany.
Dirk ReinholdInstitute of Molecular and Clinical Immunology, Otto von Guerike University Magdeburg, Magdeburg, Germany.ORCID http://orcid.org/0000-0002-6441-9631
Anja E HauserDepartment of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Anja OsterlohDepartment of Pathology, University Medical Center Ulm, Ulm, Germany.
Philipp EnghardDepartment of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jana IhlowDepartment of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Sefer ElezkurtajDepartment of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-1699-1270
David HorstDepartment of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Florian KurthDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-3807-473X
Marcel A MüllerInstitute of Virology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-2242-5117
Nils C GassenDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-4265-3398
Julia MelchertInstitute of Virology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-0494-1022
Katharina JechowCenter of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Bernd TimmermannMax Planck Institute for Molecular Genetics, Berlin, Germany.
Camila Fernandez-ZapataExperimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-4795-6053
Chotima BöttcherExperimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-6226-586X
Werner StenzelDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Elke KrügerInstitute of Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-2551-242X
Markus LandthalerMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID http://orcid.org/0000-0002-1075-8734
Emanuel WylerMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID http://orcid.org/0000-0002-9884-1806
Victor CormanDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-3605-0136
Christine StadelmannDepartment of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1766-5458
Markus RalserCore Facility High Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-9535-7413
Roland EilsCenter of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Frank L HeppnerDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-9816-8917
Michael MüllederCore Facility High Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-9792-3861
Christian ConradCenter of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-7036-342X
Helena RadbruchDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany. Helena.radbruch@charite.de.ORCID http://orcid.org/0000-0001-6941-3397
Charité - Universitätsmedizin Berlin · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEMax Delbrück Center · DEUniversitätsmedizin Göttingen · DEUniversitätsmedizin Greifswald · DEOtto-von-Guericke-Universität Magdeburg · DEGerman Center for Infection Research · DEGerman Center for Neurodegenerative Diseases · DELeibniz Association · DEMax Planck Institute for Molecular Genetics · DEUniversität Ulm · DEUniversity Hospital Bonn · DE
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) CRC 130 TP17Deutsche Forschungsgemeinschaft (German Research Foundation) CRC130 TP17Deutsche Forschungsgemeinschaft (German Research Foundation) EXC-2049-390688087Deutsche Forschungsgemeinschaft (German Research Foundation) HA 5354/10-1Deutsche Forschungsgemeinschaft (German Research Foundation) HE 3130/6-1Deutsche Forschungsgemeinschaft (German Research Foundation) RA 2491/1Deutsche Forschungsgemeinschaft (German Research Foundation) SFB TRR 167
Abstract
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the mechanisms that contribute to this remain unclear. Here we profiled single-nucleus transcriptomes and proteomes of brainstem tissue from deceased individuals at various stages of COVID-19. We detected an inflammatory type I interferon response in acute COVID-19 cases, which resolves in the late disease phase. Integrating single-nucleus RNA sequencing and spatial transcriptomics, we could localize two patterns of reaction to severe systemic inflammation, one neuronal with a direct focus on cranial nerve nuclei and a separate diffuse pattern affecting the whole brainstem. The latter reflects a bystander effect of the respiratory infection that spreads throughout the vascular unit and alters the transcriptional state of mainly oligodendrocytes, microglia and astrocytes, while alterations of the brainstem nuclei could reflect the connection of the immune system and the central nervous system via, for example, the vagus nerve. Our results indicate that even without persistence of severe acute respiratory syndrome coronavirus 2 in the central nervous system, local immune reactions are prevailing, potentially causing functional disturbances that contribute to neurological complications of COVID-19.
Indexed as
COVID-19Brain StemCerebellumGene Expression ProfilingHumansProteomics
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