ArticleNature neuroscience2024
Ripple-locked coactivity of stimulus-specific neurons and human associative memory.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Article
- Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval.Nature communications · 2026Article
- Long-term memory reorganization of navigational episodes.Nature human behaviour · 2026Article
- Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.Nature neuroscience · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- Article
- Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Evaluating place cell detection methods in Rats and Humans: Implications for cross-species spatial coding.PLoS computational biology · 2026Article
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- Long-Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans.Nature communications · 2025Article
- Hippocampal Ripples during Offline Periods Predict Human Motor Sequence Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Reasoning with programs in replay.bioRxiv : the preprint server for biology · 2025Article
- Beta bursts mediate amygdala gating of hippocampal emotional encoding.bioRxiv : the preprint server for biology · 2025Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.bioRxiv : the preprint server for biology · 2025Article
- Evaluating Place Cell Detection Methods in Rats and Humans - Implications for Cross-Species Spatial Coding: Place Cell Detection and Cross-Species Spatial Coding.bioRxiv : the preprint server for biology · 2025Article
- Coordinated hippocampal-entorhinal representations support human context-dependent spatial navigation.PLoS biology · 2025Article
- Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural basis, we investigated whether associative memory involves temporally correlated spiking of medial temporal lobe (MTL) neurons that exhibit stimulus-specific tuning. Using single-neuron recordings from patients with epilepsy performing an associative object-location memory task, we identified the object-specific and place-specific neurons that represented the separate elements of each memory. When patients encoded and retrieved particular memories, the relevant object-specific and place-specific neurons activated together during hippocampal ripples. This ripple-locked coactivity of stimulus-specific neurons emerged over time as the patients' associative learning progressed. Between encoding and retrieval, the ripple-locked timing of coactivity shifted, suggesting flexibility in the interaction between MTL neurons and hippocampal ripples according to behavioral demands. Our results are consistent with a cellular account of associative memory, in which hippocampal ripples coordinate the activity of specialized cellular populations to facilitate links between stimuli.
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