ReviewThe Plant cell2024
Nitrogen sensing and regulatory networks: it's about time and space.
Review in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual-Purpose Defense Metabolite inPlant direct · 2026Article
- HHO5 orchestrates dose-dependent feedback regulation of organic versus inorganic nitrogen signaling in Arabidopsis.The Plant cell · 2026Article
- Nitrogen form substitution identifies nitrogen use efficiency management pathways in maize.Physiology and molecular biology of plants : an international journal of functional plant biology · 2026Article
- OsGSK2-OsTCP19 Module Integrates Nitrogen and Brassinosteroid Signaling to Regulate Nitrogen Utilization and Root Growth in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Breeding-Informed Regulatory Screen Identifies ZmSPL19 as a Negative Regulator of Nitrogen-Sufficient Growth in Maize (Plants (Basel, Switzerland) · 2026Article
- The Medicago SPX1/3-PHR2 network relays phosphate signaling to orchestrate root nodulation-dependent nitrogen acquisition by controlling flavonoid biosynthesis.Plant communications · 2026Article
- A GA-independent, membrane-associated pathway regulates DELLA degradation during carbon/nitrogen stress.The Plant cell · 2026Article
- Nitrogen starvation induces arbuscular mycorrhizal fungi to optimize resource allocation in sugarcane roots via suppression of basal metabolism.NPJ biofilms and microbiomes · 2026Article
- Integrated single cell transcriptomics analysis for unraveling heterogeneity and plasticity of root cells for sustainable and regenerative agriculture.Frontiers in plant science · 2026Review
- High-throughput screening for biostimulant discovery: opportunities to enhance nitrogen use efficiency.Frontiers in plant science · 2026Review
- Genome-Wide Identification of theGenes · 2025Article
- Decoding nitrogen uptake efficiency in maize and sorghum: insights from comparative gene regulatory networks.The Plant journal : for cell and molecular biology · 2025Article
- OsNRT1.1B-OsCNGC14/16-CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nitrate to spark parched plants.Nature plants · 2025Article
- Adaptation of seed dormancy to maternal climate occurs via intergenerational transport of abscisic acid.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Trans-organ analysis of gene co-expression networks reveals a mobile long-distance regulator that balances shoot and root development in Arabidopsis.Nature plants · 2025Article
- Translational insights into abiotic interactions: From Arabidopsis to crop plants.The Plant cell · 2025Review
- Cracking the seed code: How nitrate directly breaks ABA signaling for germination.The Plant cell · 2025Article
- Model-to-crop conserved NUE Regulons enhance machine learning predictions of nitrogen use efficiency.The Plant cell · 2025Article
- Shining light on Arabidopsis regulatory networks integrating nitrogen use and photosynthesis.The Plant journal : for cell and molecular biology · 2025Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
A plant's response to external and internal nitrogen signals/status relies on sensing and signaling mechanisms that operate across spatial and temporal dimensions. From a comprehensive systems biology perspective, this involves integrating nitrogen responses in different cell types and over long distances to ensure organ coordination in real time and yield practical applications. In this prospective review, we focus on novel aspects of nitrogen (N) sensing/signaling uncovered using temporal and spatial systems biology approaches, largely in the model Arabidopsis. The temporal aspects span: transcriptional responses to N-dose mediated by Michaelis-Menten kinetics, the role of the master NLP7 transcription factor as a nitrate sensor, its nitrate-dependent TF nuclear retention, its "hit-and-run" mode of target gene regulation, and temporal transcriptional cascade identified by "network walking." Spatial aspects of N-sensing/signaling have been uncovered in cell type-specific studies in roots and in root-to-shoot communication. We explore new approaches using single-cell sequencing data, trajectory inference, and pseudotime analysis as well as machine learning and artificial intelligence approaches. Finally, unveiling the mechanisms underlying the spatial dynamics of nitrogen sensing/signaling networks across species from model to crop could pave the way for translational studies to improve nitrogen-use efficiency in crops. Such outcomes could potentially reduce the detrimental effects of excessive fertilizer usage on groundwater pollution and greenhouse gas emissions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.