Evidence map›Paper›PMID 38366081›Full record

ArticleArchives of virology2024

Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis.

Naganori Nao, Tomohiro Okagawa, Naomi Nojiri, Satoru Konnai, Honami Shimakura, Misono Tominaga, Hazuka Yoshida-Furihata, Eri Nishiyama, Takahiro Matsudaira, Naoya Maekawa and 4 more

Abstract read
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In one paragraph

Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Naganori NaoDivision of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Tomohiro OkagawaDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Naomi NojiriCenter for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo, Japan.
Satoru KonnaiDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan. konnai@vetmed.hokudai.ac.jp.
Honami ShimakuraDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Misono TominagaDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Hazuka Yoshida-FurihataCenter for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo, Japan.
Eri NishiyamaBiotechnological Research Support Division, FASMAC Co., Ltd, Atsugi, Japan.
Takahiro MatsudairaBiotechnological Research Support Division, FASMAC Co., Ltd, Atsugi, Japan.
Naoya MaekawaDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Shiro MurataDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Masamichi MuramatsuDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Kazuhiko OhashiDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Masumichi SaitoCenter for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo, Japan. saitomas@niid.go.jp.ORCID http://orcid.org/0000-0001-7187-1186
Hokkaido University · JPNational Institute of Infectious Diseases · JPSapporo University · JP

Funding

Clinical Research Promotion Fund by the Hokkaido University Veterinary Teaching Hospital Clinical Research Promotion Fund by the Hokkaido University Veterinary Teaching HospitalIto Memorial Foundation Ito Memorial FoundationJapan Agency for Medical Research and Development HU-IVReDJapan Agency for Medical Research and Development JP22wm0125008Japan Society for the Promotion of Science 17H03594Japan Society for the Promotion of Science 19K15993Japan Society for the Promotion of Science 19KK0172Japan Society for the Promotion of Science 22H02503Japan Society for the Promotion of Science 22K15005Japan Society for the Promotion of Science 22K19232Japan Society for the Promotion of Science 23HA2010The NARO Bio-oriented Technology Research Advancement Institution 16817557The Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry 26058BWorld-leading Innovative and Smart Education Program 1801 from the Ministry of Education, Culture , Sports, Science and Technology World-leading Innovative and Smart Education Program 1801 from the Ministry of Education, Culture , Sports, Science and Technology
6 · The paper itself

Abstract

Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3-9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.

Indexed as

Enzootic Bovine LeukosisLeukemia Virus, BovineAnimalsCattleFemaleProviruses

Identifiers

PMID38366081
OpenAlexW4391885616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.