Trial reportNature medicine2024
Anxiety-focused cognitive behavioral therapy delivered by non-specialists to prevent postnatal depression: a randomized, phase 3 trial.
Trial report in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03880032 (Happy Mother-Healthy Baby), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention for the Prevention of Common Mental Disorders in Pakistan
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Effect of mindfulness stress reduction combined with cognitive behavioral therapy on perinatal anxiety disorder and maternal-infant bonding.World journal of psychiatry · 2025Trial
- An intervention to address prenatal anxiety improves maternal-infant bonding, with effects mediated by maternal-infant responsiveness, maternal self-efficacy, and postpartum depression.Infant mental health journal · 2025Trial
- Task-sharing and telemedicine delivery of psychotherapy to treat perinatal depression: a pragmatic, noninferiority randomized trial.Nature medicine · 2025Trial
- A psychosocial intervention for prenatal anxiety decreases functional disability among pregnant Pakistani women: A moderated mediation approach using data from a randomized controlled trial.Journal of psychosomatic research · 2025Trial
- Multiple mediation analysis of a task-shared psychosocial intervention for perinatal anxiety: Exploratory findings from a randomized controlled trial in Pakistan.Journal of affective disorders · 2024Trial
- Impact of an intervention for perinatal anxiety on breastfeeding: findings from the Happy Mother-Healthy Baby randomized controlled trial in Pakistan.International breastfeeding journal · 2024Trial
- Results of a cognitive behavior therapy-based intervention for antenatal anxiety on birth outcomes in Pakistan: a randomized control trial.Scientific reports · 2024Trial
- Effects of a Prenatal Anxiety Randomized Controlled Trial Intervention on Infant Development in Pakistan.Academic pediatricsTrial
- Developing a core outcome set for generalized anxiety disorder during the perinatal period: Identifying core treatment outcomes in perinatal anxiety.The British journal of clinical psychology · 2026Article
- Advances in Perinatal Depression: A Focus on Screening and Treatment.Journal of clinical medicine · 2026Review
- Effectiveness of psychological interventions for reducing depressive symptoms among women experiencing perinatal depression: a systematic review.AJOG global reports · 2026Review
- "It's Harder to Chase Pain Than It Is to Prevent It": Perinatal Individual and Care Professional Attitudes Towards Preventing Perinatal Mood and Anxiety Disorders in Obstetric Settings.The Psychiatric quarterly · 2026Article
- The adjunctive effect of a qigong (Baduanjin) intervention program on maternal and child health outcomes: a multicenter randomized controlled trial protocol.BMC pregnancy and childbirth · 2026Article
- Vitamin D levels and perinatal anxiety in an anxiety-focused behavioral intervention program in Pakistan.Archives of women's mental health · 2026Article
- Awareness, Attitudes, and Help-Seeking Intention Towards Perinatal Depression Among Women from Different Ethnic Groups in Western Rural China.International journal of women's health · 2026Article
- Perinatal anxiety and compromised bond: A qualitative study of cultural scripts, structural barriers and maternal emotional negotiations in Pakistan.Global mental health (Cambridge, England) · 2026Article
- Doula-Delivered Cognitive Behavioral Training and Cardiovascular Health Intervention for Birthing Individuals in a Low-Income New York City Population: Protocol for a Living Healthy for Moms Randomized Type I Hybrid Effectiveness-Implementation Trial.JMIR research protocols · 2025Article
- The prenatal anxiety trajectory and its correlation with stress and psychological flexibility: a longitudinal study.BMC psychology · 2025Article
- Navigating perinatal mental health integration in maternal and child health services: progress and priorities for research and practices in Pakistan.BJPsych international · 2025Review
- Receipt of a psychosocial intervention for prenatal anxiety and risk of perinatal intimate partner violence in Pakistani women.PLOS global public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Anxiety experienced by women during pregnancy is highly prevalent, especially in resource-poor settings and strongly predicts postnatal common mental disorders (CMDs), anxiety and depression. We evaluated the effectiveness of an anxiety-focused early prenatal intervention on preventing postnatal CMDs. This study was a phase 3, two-arm, single-blind, randomized controlled trial conducted in Pakistan with women who were ≤22 weeks pregnant and had at least mild anxiety without clinical depression. Participants were randomized to the Happy Mother-Healthy Baby program, based on cognitive behavioral therapy, consisting of six one-on-one intervention sessions in pregnancy delivered by non-specialist providers, or to enhanced care alone. The primary outcome was major depression, generalized anxiety disorder or both at 6 weeks after delivery. Overall, 755 women completed postnatal assessments (380 (50.3%), intervention arm; 375 (49.7%) enhanced-care arm). The primary outcomes were met. Examined jointly, we found 81% reduced odds of having either a major depressive episode (MDE) or moderate-to-severe anxiety for women randomized to the intervention (adjusted odds ratio (aOR) = 0.19, 95% CI 0.14-0.28). Overall, 12% of women in the intervention group developed MDE at 6 weeks postpartum, versus 41% in the control group. We found reductions of 81% and 74% in the odds of postnatal MDE (aOR = 0.19, 95% CI 0.13-0.28) and of moderate-to-severe anxiety (aOR = 0.26, 95% CI 0.17-0.40), respectively. The Happy Mother-Healthy Baby program early prenatal intervention focusing on anxiety symptoms reduced postpartum CMDs. ClinicalTrials.gov identifier NCT03880032 .
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.