ArticleScientific reports2024
cnnImpute: missing value recovery for single cell RNA sequencing data.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- scZiva: imputation method for single-cell RNA-seq data with zero-inflated variational autoencoder.BMC bioinformatics · 2026Article
- Artificial Intelligence Revolution in Transcriptomics: From Single Cells to Spatial Atlases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Pseudotime-conditioned diffusion models for imputing time-series single-cell data.Bioinformatics advances · 2026Article
- Applications of AI to single-cell and spatial transcriptomics: current state-of-the-art and challenges.Frontiers in bioinformatics · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
The advent of single-cell RNA sequencing (scRNA-seq) technology has revolutionized our ability to explore cellular diversity and unravel the complexities of intricate diseases. However, due to the inherently low signal-to-noise ratio and the presence of an excessive number of missing values, scRNA-seq data analysis encounters unique challenges. Here, we present cnnImpute, a novel convolutional neural network (CNN) based method designed to address the issue of missing data in scRNA-seq. Our approach starts by estimating missing probabilities, followed by constructing a CNN-based model to recover expression values with a high likelihood of being missing. Through comprehensive evaluations, cnnImpute demonstrates its effectiveness in accurately imputing missing values while preserving the integrity of cell clusters in scRNA-seq data analysis. It achieved superior performance in various benchmarking experiments. cnnImpute offers an accurate and scalable method for recovering missing values, providing a useful resource for scRNA-seq data analysis.
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