ArticleNature communications2024
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.
Erratum issuedOpen access · goldAbstract read
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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31citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
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Who cites it
31 citing papers in PubMed, 36 citations in OpenAlex.
- Hepatic PDIA5 improves hyperglycaemia and insulin resistance through stabilisation of ATF6.Diabetologia · 2026Article
- ERO1L induces macrophage infiltration to potentiate KrasCell & bioscience · 2026Article
- Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases.Signal transduction and targeted therapy · 2026Review
- SEL1L3 suppresses colorectal cancer cell growth and metastasis by preventing endoplasmic reticulum-associated degradation of STING.Cell death & disease · 2026Article
- Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing.The EMBO journal · 2026Article
- SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.Nature communications · 2026Article
- The Hrd1-Mediated ERAD Pathway in Plants: Conserved Principles and Plant-Specific Innovations.International journal of molecular sciences · 2026Review
- Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.Nature communications · 2026Article
- Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis.The Journal of clinical investigation · 2026Article
- Loss of SEL1L or Hrd1 increases intrinsic LOX levels in HEK293 cells independently of proteasomal degradation.Molecular biology reports · 2026Article
- The role of ER-associated degradation and ER-phagy in health and disease.Signal transduction and targeted therapy · 2026Review
- Meta-analysis of functional genomics studies reveals conserved cellular pathways required by viruses of pandemic concern.Access microbiology · 2026Article
- From organelles to therapy: rethinking combined hepatocellular-cholangiocarcinoma.Frontiers in cell and developmental biology · 2026Review
- TAPT1 interacts with SUCO to maintain the homeostasis of newly synthesized proteins and brain development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- HSPA12B Protects Against Age-Related Endothelial Cell Senescence by Regulating STING Degradation.Aging cell · 2025Article
- SEL1L confers reduced EMT and drug resistance to breast cancer cells by promoting Shh degradation.iScience · 2025Article
- SEL1L-HRD1-mediated ERAD in mammals.Nature cell biology · 2025Review
- Structural insights into the human HRD1 ubiquitin ligase complex.Nature communications · 2025Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
14 authors at 3 institutions in 1 country.
Liangguang Leo LinDepartment of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA.ORCID 0000-0003-1414-610X
Huilun Helen WangDepartment of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA.
Brent PedersonDepartment of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.
Xiaoqiong WeiDepartment of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA.ORCID 0000-0001-7576-4820
Mauricio TorresDepartment of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.
You LuDepartment of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.ORCID 0000-0002-0075-8167
Zexin Jason LiDepartment of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA.
Xiaodan LiuZilkha Neurogenetic Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA.
Hancheng MaoDepartment of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.ORCID 0000-0003-2546-6774
Hui WangDepartment of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA.
Linyao Elina ZhouDepartment of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA.
Zhen ZhaoZilkha Neurogenetic Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA.ORCID 0000-0001-8967-5570
Shengyi SunDepartment of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA, 22908, USA. bjk5fz@virginia.edu.ORCID 0000-0002-1734-3902
Ling QiDepartment of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA. xvr2hm@virginia.edu.ORCID 0000-0001-8229-0184
University of Virginia · USUniversity of Michigan · USUniversity of Southern California · US
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MNovel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9MERAD-STING Crosstalk in Microglia: Unraveling the Pathogenesis of Alzheimer's DiseaseR01AG089640 · NIA · UNIVERSITY OF VIRGINIA · PI Ling Qi, Zhen Zhao · 2024 to 2026
$4.1MUnderstanding Neural Bases for Neuropsychiatric Impairments in Alzheimer's Disease ModelsR01AG089756 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Huizhong Whit Tao, Zhen Zhao · 2024 to 2026
$3.6MRegulation of Mitochondrial Dynamics by ERAD: Administrative SupplementR35GM130292 · NIGMS · UNIVERSITY OF VIRGINIA · PI QI, LING · 2019 to 2023
$2.5MThe role of ATP13A5 ATPase in determining blood-brain pericyte functionsRF1NS135617 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2023 to 2023
$2.4MA TIMEM252-dependent Microvascular Endophenotype in Alzheimer’s DiseaseRF1NS122060 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2021 to 2021
$2.3MPericyte-neuronal crosstalk in health and Alzheimer's DiseaseR01AG061288 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2023
$2.1MNovel role of endoplasmic reticulum-associated degradation in iron metabolismR01DK128077 · NIDDK · WAYNE STATE UNIVERSITY · PI Shengyi Sun · 2022 to 2026
$1.9MDefining the Central Role of ER-Associated Degradation (ERAD) in Neuroendocrine CellsR01DK120047 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QI, LING · 2018 to 2021
$1.6MNIAMS NIH HHS P30 AR069620NIA NIH HHS R01 AG061288NIA NIH HHS R01 AG089756NIA NIH HHS R21 AG085559NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK120047NIDDK NIH HHS R01 DK120330NIDDK NIH HHS R01 DK128077NIDDK NIH HHS R01 DK132068NIDDK NIH HHS R01 DK132786NIDDK NIH HHS R01 DK137794NIGMS NIH HHS R35 GM130292NIH HHS S10 OD028612NINDS NIH HHS R01 NS122060NINDS NIH HHS RF1 NS122060NINDS NIH HHS RF1 NS135617
Abstract
The SEL1L-HRD1 protein complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in both mouse models and humans, in vivo evidence for the importance of SEL1L in the ERAD complex formation and its (patho-)physiological relevance in mammals remains limited. Here we report that SEL1L variant p.Ser658Pro (SEL1L
Indexed as
Endoplasmic Reticulum-Associated DegradationProteinsAnimalsDisease Models, AnimalIntracellular Signaling Peptides and ProteinsMammalsMiceProteomicsUbiquitin-Protein LigasesIntracellular Signaling Peptides and ProteinsProteinsSel1h protein, mouseSyvn1 protein, mouseUbiquitin-Protein Ligases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.