ArticleJournal of translational medicine2024
Association between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study.
Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Research advances in physical activity and insomnia: a bibliometric and thematic evolution analysis.Frontiers in psychiatry · 2026Pooled it
- Telomere length dynamics do not predict subclinical atherosclerosis progression over a six-year period.GeroScience · 2026Article
- PhenoAge acceleration, serum tryptophan, and frailty in socially engaged actively aging elderly men.iScience · 2026Article
- Different dimensions of smoking behavior and their associations with accelerated composite biomarkers-based biological aging in Chinese older adults.BMC geriatrics · 2025Article
- Impact of smoking and alcohol consumption on telomere length: A univariable and multivariable Mendelian randomization study.Medicine · 2025Article
- Telomere Length, Epigenetic Age Acceleration, and Mortality Risk in US Adult Populations: An Additive Bayesian Network Analysis.Aging cell · 2025Article
- Sedentary lifestyle, physical activity, and aging: evidence from genetic correlation and mendelian randomization.Aging clinical and experimental research · 2025Article
- Telomeres in skin aging.Biogerontology · 2025Review
- Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study.Epigenomics · 2025Article
- Targeting telomere dynamics with plant-derived compounds: Molecular strategies against aging.Current research in pharmacology and drug discovery · 2025Review
- Premature aging and metabolic diseases: the impact of telomere attrition.Frontiers in aging · 2025Review
- Association of self-reported sleep duration with leukocyte telomere length in type 2 diabetes mellitus patients.Frontiers in endocrinology · 2025Article
- The Notable Role of Telomere Length Maintenance in Complex Diseases.Biomedicines · 2024Review
- Telomere length as a biomarker for cerebrovascular diseases: current evidence.Molecular biology reports · 2024Review
- Stress Hormones: Unveiling the Role in Accelerated Cellular Senescence.Aging and disease · 2024Review
- Exploring the mediating role of calcium homeostasis in the association between diabetes mellitus, glycemic traits, and vascular and valvular calcifications: a comprehensive Mendelian randomization analysis.Diabetology & metabolic syndrome · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTelomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservation; however, the association between lifestyle factors and telomere length remains controversial. To address this issue, we conducted a Mendelian randomization (MR) analysis to investigate the potential causal associations between multiple lifestyle factors and telomere length.
methodsIndependent genetic variants strongly associated with lifestyle factors (tobacco smoking, sleep duration, insomnia, and physical activity) were selected as instrumental variables from corresponding genome-wide association studies (GWASs). Summary-level data for telomere length was obtained from a GWAS comprising 472,174 European ancestries. Univariable and multivariable MR analyses were performed to assess the relationships.
resultsThe genetic liability to lifetime smoking was robustly associated with shorter telomere length (odd ratio [OR]: 0.882; 95% confidence interval [CI]: 0.847-0.918). Genetically predicted insomnia was also linked to shorter telomere length (OR: 0.972; 95% CI: 0.959-0.985), while no significant association was observed between sleep duration and telomere length. Furthermore, a suggestive association was found between moderate-to-vigorous physical activity and longer telomere length (OR: 1.680; 95% CI: 1.115-2.531). In multivariable MR analyses, adjusting for potential mediators such as body mass index, type 2 diabetes, alcohol consumption, and alcohol use disorder, the associations of lifetime smoking and insomnia with telomere length remained robust.
conclusionOur findings suggest that smoking and insomnia may contribute to telomere shortening, while physical activity may play a role in telomere length maintenance. These findings underscore the importance of managing positive risk factors and adopting a healthy lifestyle to promote telomere health.
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