Evidence map›Paper›PMID 38365676›Full record

ArticleBMC complementary medicine and therapies2024

Chemical composition, anticancer, antimicrobial activity of Aloysia citriodora Palau essential oils from four different locations in Palestine.

Nawaf Al-Maharik, Yousef Salama, Nisreen Al-Hajj, Nidal Jaradat, Naji Thaer Jobran, Ismael Warad, Lina Hamdan, Moataz Abo Alrob, Asil Sawafta, Adel Hidmi

Open access · goldAbstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Nutrients · 2025
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  4. Article
  5. ChileanPlants (Basel, Switzerland) · 2025
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  6. Article
  7. Review
  8. Article
  9. Bioprospecting for Anti-Kinetoplastid Drug Discovery fromInternational journal of molecular sciences · 2025
    Article
  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nawaf Al-MaharikDepartment of Chemistry, Faculty of Sciences, An-Najah National University, Nablus P.O. Box. 7, Nablus, 99900800, Palestine. n.maharik@najah.edu.
Yousef SalamaAn-Najah Center for Cancer and Stem Cell Research, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, 00970, Palestine.
Nisreen Al-HajjDepartment of Chemistry, Faculty of Sciences, An-Najah National University, Nablus P.O. Box. 7, Nablus, 99900800, Palestine.
Nidal JaradatDepartment of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, P.O. Box. 7, Palestine.
Naji Thaer JobranDepartment of Chemistry, Faculty of Sciences, Birzeit University, Birzeit, P.O. Box. 7, Palestine.
Ismael WaradDepartment of Chemistry, Faculty of Sciences, An-Najah National University, Nablus P.O. Box. 7, Nablus, 99900800, Palestine.
Lina HamdanDepartment of Chemistry, Faculty of Sciences, An-Najah National University, Nablus P.O. Box. 7, Nablus, 99900800, Palestine.
Moataz Abo AlrobDepartment of Chemistry, Faculty of Sciences, An-Najah National University, Nablus P.O. Box. 7, Nablus, 99900800, Palestine.
Asil SawaftaAn-Najah Center for Cancer and Stem Cell Research, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, 00970, Palestine.
Adel HidmiDepartment of Chemistry, Faculty of Sciences, Birzeit University, Birzeit, P.O. Box. 7, Palestine.
An-Najah National University · PSBirzeit University · PS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primary aim of this investigation was to determine the anticancer and antimicrobial properties of essential oils (EOs) extracted from the leaves of Aloysia citriodora Palau, which were procured from four separate locations in Palestine, in addition to analyzing their chemical composition. These areas include Jericho, which has the distinction of being the lowest location on Earth, at 260 m below sea level. The EOs were acquired by hydrodistillation, and their chemical composition was examined utilizing gas chromatography-mass spectrometry (GC-MS). The minimum inhibitory concentration (MIC) of EOs was assessed against six bacterial strains and one fungal species using 96-well microtiter plates. The primary components found in these oils are geranial (26.32-37.22%), neral (18.38-29.00%), and α-curcumene (7.76-16.91%) in three regions. α-Curcumene (26.94%), spathulenol (13.69%), geranial (10.79%), caryophyllene oxide (8.66%), and neral (7.59%) were found to be the most common of the 32 chemical components in the EO from Jericho. The EOs exhibited bactericidal properties, particularly against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and showed highly effective fungicidal activity. Nevertheless, the antifungal efficacy of the EO was found to surpass its antibacterial activity when administered at lower dosages. The EOs exhibited anticancer activities against melanoma cancer cells, as indicated by their IC

Indexed as

Acyclic MonoterpenesAnti-Infective AgentsMethicillin-Resistant Staphylococcus aureusOils, VolatileSesquiterpenesVerbenaceaeAnti-Bacterial AgentsAntifungal AgentsPalauAcyclic Monoterpenesalpha-curcumeneAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentscitralOils, VolatileSesquiterpenesAloysia citriodoraAntibacterialAntifungalColorectal cancerPhytochemicals

Identifiers

PMID38365676
PMCPMC10870676
OpenAlexW4391882319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.