Evidence map›Paper›PMID 38365584›Full record

ArticleBMC geriatrics2024

Stability and consistency of symptom clusters in younger versus older patients receiving chemotherapy.

Lisa Morse, Bruce A Cooper, Christine S Ritchie, Melisa L Wong, Kord M Kober, Carolyn Harris, Joosun Shin, Kate Oppegaard, Marilyn J Hammer, Alejandra Calvo Schimmel and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Lisa MorseSchool of Nursing, University of California, San Francisco, CA, USA.
Bruce A CooperSchool of Nursing, University of California, San Francisco, CA, USA.
Christine S RitchieDivision of Palliative Care and Geriatric Medicine, Massachusetts General Hospital Morgan Institute, Boston, MA, USA.
Melisa L WongSchool of Medicine, University of California, San Francisco, CA, USA.
Kord M KoberSchool of Nursing, University of California, San Francisco, CA, USA.
Carolyn HarrisSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Joosun ShinDana Farber Cancer Institute, Boston, MA, USA.
Kate OppegaardDana Farber Cancer Institute, Boston, MA, USA.
Marilyn J HammerDana Farber Cancer Institute, Boston, MA, USA.
Alejandra Calvo SchimmelSchool of Nursing, University of California, San Francisco, CA, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, CA, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, CA, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, CA, USA. chris.miaskowski@ucsf.edu.
University of California, San Francisco · USDana-Farber Cancer Institute · USUniversity of Pittsburgh · USKaiser Permanente Oakland Medical Center · USMassachusetts General Hospital · US

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Targeting Research and Academic Training of Nurses in GenomicsT32NR009759 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2006 to 2025
$4.5M
NCI NIH HHS R01 CA134900NINR NIH HHS NR009759NINR NIH HHS T32 NR009759
6 · The paper itself

Abstract

backgroundBy 2035, the number of newly diagnosed cancer cases will double and over 50% will be in older adults. Given this rapidly growing demographic, a need exists to understand how age influences oncology patients' symptom burden. The study purposes were to evaluate for differences in the occurrence, severity, and distress of 38 symptoms in younger (< 60 years) versus older (≥ 60 years) oncology patients undergoing chemotherapy and to evaluate for differences in the stability and consistency of symptom clusters across the two age groups.

methodsA total of 1329 patients were dichotomized into the younger and older groups. Patients completed demographic and clinical questionnaires prior to the initiation of their second or third cycle of chemotherapy. A modified version of Memorial Symptom Assessment Scale was used to evaluate the occurrence, severity, and distress of 38 common symptoms associated with cancer and its treatment. Differences between the two age groups in demographic and clinical characteristics and ratings of occurrence, severity, and distress for the 38 symptoms were evaluated using parametric and nonparametric tests. Exploratory factor analyses were done within each age group to identify symptom clusters using symptom occurrence rates.

resultsCompared to the younger group (14.8 (± 7.0)), older adults reported a lower mean number of symptoms (12.9 (± 7.2)). Older patients experienced lower occurrence rates for almost 50% of the symptoms. Regarding symptom clusters, an eight-factor solution was selected for both age groups. Across the two age groups, the eight symptom clusters (i.e., physical and cognitive fatigue, respiratory, psychological, hormonal, chemotherapy-related toxicity, weight gain, gastrointestinal, epithelial) were stable. However, symptoms within the physical and cognitive, chemotherapy-related toxicity, and gastrointestinal clusters were not consistent across the age groups.

conclusionsTo be able to provide tailored and effective symptom management interventions to older oncology patients, routine assessments of the core symptoms unique to the symptom clusters identified for this group warrants consideration. The underlying mechanism(s) for these inconsistencies in symptom burden is an important focus for future studies.

Indexed as

Antineoplastic AgentsNeoplasmsAgedHumansLongitudinal StudiesSeverity of Illness IndexSyndromeAntineoplastic AgentsCancerChemotherapyExploratory factor analysisOlder adultsPatient reported outcomesSymptom clustersSymptoms

Identifiers

PMID38365584
PMCPMC10870638
OpenAlexW4391884073

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.