Evidence map›Paper›PMID 38365446›Full record

Trial reportArchives of disease in childhood. Fetal and neonatal edition2024

Extended CPAP or low-flow nasal cannula for intermittent hypoxaemia in preterm infants: a 24-hour randomised clinical trial.

Siamak Yazdi, Waldemar A Carlo, Arie Nakhmani, Ernestina O Boateng, Immaculada Aban, Namasivayam Ambalavanan, Colm P Travers

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04792099 (CPAP Or Nasal Cannula Oxygen for Preterm Infants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04792099 nacompletednot on this map

CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2021 to 2023Enrolled38ConditionsInfant, Newborn, Disease, Hypoxia, Respiratory Distress Syndrome, Bronchopulmonary DysplasiaArmsContinuous positive airway pressure, Nasal Cannula
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Siamak YazdiDepartment of Pediatrics, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA syazdi@uabmc.edu.ORCID http://orcid.org/0009-0007-7856-9984
Waldemar A CarloDepartment of Pediatrics, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Arie NakhmaniDepartment of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ernestina O BoatengDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Immaculada AbanDepartment of Pediatrics, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Namasivayam AmbalavananDepartment of Pediatrics, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Colm P TraversDepartment of Pediatrics, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.ORCID http://orcid.org/0000-0002-3218-1024
University of Alabama at Birmingham · US

Funding

Pre-Vent ApneaU01HL133536 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM, INDIC, PREMANANDA PAI · 2016 to 2020
$2.6M
Non-invasive oscillometry to measure lung mechanics, response to treatments, and predict longer-term pulmonary outcomes among preterm infants: a prospective cohort studyK23HL157618 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Colm Peter Travers · 2022 to 2026
$862k
NHLBI NIH HHS K23 HL157618NHLBI NIH HHS U01 HL133536
6 · The paper itself

Abstract

objectiveOptimal timing of continuous positive airway pressure (CPAP) cessation in preterm infants remains undetermined. We hypothesised that CPAP extension compared with weaning to low-flow nasal cannula (NC) reduces intermittent hypoxaemia (IH) and respiratory instability in preterm infants meeting criteria to discontinue CPAP.

designSingle-centre randomised clinical trial.

settingLevel 4 neonatal intensive care unit. PATIENTS: 36 infants <34 weeks' gestation receiving CPAP≤5 cmH

interventionsExtended CPAP was compared with weaning to low-flow NC (0.5 L/kg/min with a limit of 1.0 L/min) for 24 hours. OUTCOMES: The primary outcome was IH (number of episodes with SpO

resultsThe median (IQR) episodes of IH per 24-hour period was 20 (6-48) in the CPAP group and 76 (18-101) in the NC group (p=0.03). Infants continued on CPAP had less bradycardia, time with SpO

conclusionIn preterm infants meeting respiratory stability criteria for CPAP cessation, extended CPAP decreased IH, bradycardia and other hypoxaemia measures compared with weaning to low-flow NC during the 24-hour intervention. TRIAL REGISTRATION NUMBER: NCT04792099.

Indexed as

CannulaContinuous Positive Airway PressureHypoxiaInfant, PrematureBradycardiaFemaleHumansInfant, NewbornIntensive Care Units, NeonatalMaleOxygen Inhalation TherapyOxygen SaturationRespiratory Distress Syndrome, NewbornVentilator WeaningIntensive Care Units, NeonatalNeonatologyPhysiology

Identifiers

PMID38365446
PMCPMC11327380
OpenAlexW4391885578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.