ArticleJournal of the American Chemical Society2024
Direct Bioisostere Replacement Enabled by Metallaphotoredox Deoxydifluoromethylation.
Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Article
- Synthesis and In Vivo Incorporation of 4-Difluoromethyl-L-Phenylalanine Into Proteins.Chembiochem : a European journal of chemical biology · 2026Article
- Unified Synthesis of Unconventional α-Polyhalogenated Amines Through Hydroaminoalkylation.Angewandte Chemie (International ed. in English) · 2026Article
- Redefining the Minimal Editable Unit of Supramolecular Synthons: A 1→2 Lattice-Editing Strategy in Ternary Multicomponent Crystals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Unified Platform for Direct Alkynylation from Alcohols via Deoxygenative Metallaphotoredox Catalysis.Journal of the American Chemical Society · 2026Article
- Nickel-Boryl-Catalyzed Modular Alkyl Difluoromethylation Enabled by an NMP-Stabilized ICFAngewandte Chemie (International ed. in English) · 2026Article
- Benzodithiolane-Enabled C─O Bond Activation for Deoxygenative Functionalization of Carbohydrates and Nucleosides.Angewandte Chemie (International ed. in English) · 2026Article
- Electrochemical Deoxygenative Silylation of Alcohols.Angewandte Chemie (International ed. in English) · 2025Article
- Modular synthesis of CFNature communications · 2025Article
- Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene.EJNMMI radiopharmacy and chemistry · 2025Article
- Article
- Aryl Acid-Alcohol Cross-Coupling: C(spJournal of the American Chemical Society · 2025Article
- Photo-induced decarboxylative radical cascade cyclization of unactivated alkenes: access to CF- and CFRSC advances · 2025Article
- Article
- Expanding tracer space for positron emission tomography with high molar activityNature communications · 2025Article
- Photoredox-catalyzed deoxygenative radical transformation of alcohols to sulfinamides.RSC advances · 2025Article
- Enantioconvergent copper-catalysed difluoromethylation of alkyl halides.Nature catalysis · 2024Article
- Scalable deoxygenative alkynylation of alcohols via flow photochemistry.Communications chemistry · 2024Article
- Highly Enantioselective Decarboxylative Difluoromethylation.Journal of the American Chemical Society · 2024Article
- Direct Synthesis of 2-Hydroxytrifluoroethylacetophenones via Organophotoredox-Mediated Net-Neutral Radical/Polar Crossover.The Journal of organic chemistry · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The replacement of a functional group with its corresponding bioisostere is a widely employed tactic during drug discovery campaigns that allows medicinal chemists to improve the ADME properties of candidates while maintaining potency. However, the incorporation of bioisosteres typically requires lengthy de novo resynthesis of potential candidates, which represents a bottleneck in their broader evaluation. An alternative would be to directly convert a functional group into its corresponding bioisostere at a late stage. Herein, we report the realization of this approach through the conversion of aliphatic alcohols into the corresponding difluoromethylated analogues via the merger of benzoxazolium-mediated deoxygenation and copper-mediated C(sp
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.