Evidence map›Paper›PMID 38364961›Full record

ArticleCancer letters2024

Interplay between B7-H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma.

Giulia Cattaneo, Marco Ventin, Shahrzad Arya, Filippos Kontos, Theodoros Michelakos, Yurie Sekigami, Lei Cai, Vincenzo Villani, Francesco Sabbatino, Francine Chen and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. B7-H3 CAR T cells eradicate intrahepatic cholangiocarcinoma and induce durable response.Journal of experimental & clinical cancer research : CR · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Chimeric Antigen Receptor T Cell with an Inducible Caspase-9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Giulia CattaneoDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: https://twitter.com/GCattaneoPhD.
Marco VentinDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Shahrzad AryaDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Filippos KontosDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Theodoros MichelakosDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Yurie SekigamiDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Lei CaiDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Vincenzo VillaniDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Francesco SabbatinoDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Francine ChenMacroGenics Inc., Rockville, MD, United States.
Ananthan SadagopanDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Vikram DeshpandeDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Paul A MooreMacroGenics Inc., Rockville, MD, United States.
David T TingMassGeneral Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Nabeel BardeesyMassGeneral Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Xinhui WangDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Soldano FerroneDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Cristina R FerroneDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Electronic address: cristina.ferrone@cshs.org.
Harvard University · USMacroGenics (United States) · USCedars-Sinai Medical Center · USTwitter (United States) · US

Funding

T cell plasticity, fusion proteins and CAR T cell-based immunotherapy of head and neck cancerR01DE028172 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, XINHUI · 2018 to 2022
$1.9M
Prevention of post-therapy breast cancer metastasisR01CA226981 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, XINHUI · 2019 to 2023
$1.8M
IL-15 TRiKES-based specific immunotherapy of pancreatic ductal adenocarcinomaR03CA231766 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FERRONE, CRISTINA R., FERRONE, SOLDANO · 2018 to 2019
$177k
Safety and anti-tumor activity of B7-H3 CAR T cells in TNBCR03CA223886 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DOTTI, GIANPIETRO, FERRONE, SOLDANO · 2018 to 2019
$176k
NCI NIH HHS R01 CA226981NCI NIH HHS R03 CA223886NCI NIH HHS R03 CA231766NIDCR NIH HHS R01 DE028172
6 · The paper itself

Abstract

Human leukocyte antigen (HLA) class I defects are associated with cancer progression. However, their prognostic significance is controversial and may be modulated by immune checkpoints. Here, we investigated whether the checkpoint B7-H3 modulates the relationship between HLA class I and pancreatic ductal adenocarcinoma (PDAC) prognosis. PDAC tumors were analyzed for the expression of B7-H3, HLA class I, HLA class II molecules, and for the presence of tumor-infiltrating immune cells. We observed defective HLA class I and HLA class II expressions in 75% and 59% of PDAC samples, respectively. HLA class I and B7-H3 expression were positively related at mRNA and protein level, potentially because of shared regulation by RELA, a sub-unit of NF-kB. High B7-H3 expression and low CD8

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsB7 AntigensB7-H1 AntigenDisease ProgressionHistocompatibility Antigens Class IHumansLymphocytes, Tumor-InfiltratingPrognosisB7 AntigensB7-H1 AntigenCD276 protein, humanHistocompatibility Antigens Class IB7–H3HLA class INF-kBPDACTumor microenvironment

Identifiers

PMID38364961
PMCPMC11146152
OpenAlexW4391825084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.