ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2024
Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multinational WE-ROCK Collaborative.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 26 citations in OpenAlex.
- An epidemiological assessment of hemodialysis, continuous kidney replacement therapy, and peritoneal dialysis in pediatric acute kidney injury patients.Renal failure · 2026Article
- Practice Patterns and Outcomes of Hemodialysis in Infants Undergoing Congenital Heart Surgery in the United States.Pediatric cardiology · 2026Article
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Fluid accumulation and outcomes in children receiving continuous kidney replacement therapy: an appraisal of the WE-ROCK registry.Pediatric nephrology (Berlin, Germany) · 2026Article
- Time from acute kidney injury to continuous renal replacement therapy and outcomes in critically ill children.Clinical kidney journal · 2026Article
- Fluid balance and acute lung injury in children and young adults receiving continuous renal replacement therapy: a report from the Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK).European journal of pediatrics · 2026Article
- Clinical Subphenotypes and Short-Term Outcomes in PICU Patients Receiving Continuous Blood Purification.Critical care explorations · 2026Article
- Antimicrobial pharmacokinetics in pediatric patients on kidney replacement therapy: a comprehensive narrative review.Pediatric nephrology (Berlin, Germany) · 2026Review
- Current status and future directions for the use of artificial intelligence in pediatric critical care nephrology.Pediatric nephrology (Berlin, Germany) · 2026Review
- Continuous renal replacement therapy for septic shock: practicalities for a pediatric intensivist.European journal of pediatrics · 2026Review
- Early post-approval experience of the selective cytopheretic device surveillance registry for pediatric AKI requiring kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Urine neutrophil gelatinase-associated lipocalin predicts kidney support therapy duration and liberation in critically ill children.Pediatric research · 2026Article
- Dialysis modality and mortality of the Contemporary Infant and Neonatal Dialysis (COINED) Cohort: a Pediatric Nephrology Research Consortium (PNRC) study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Hypophosphatemia in Pediatric Patients on Continuous Kidney Replacement Therapy-A WE-ROCK Study.Research square · 2026Article
- Observational
- Renal replacement therapy in intensive care unit: a narrative review.Annals of intensive care · 2026Review
- Are the outcomes of critically ill children undergoing pediatric continuous kidney replacement therapy actually modifiable?Pediatric nephrology (Berlin, Germany) · 2025Article
- Pediatric continuous kidney replacement therapy: The Indonesian experience.Pediatric nephrology (Berlin, Germany) · 2025Article
- Enhancing outcomes in pediatric populations with continuous renal replacement therapy: Current multidisciplinary strategies and innovations.Journal of intensive medicine · 2025Review
- Continuous Kidney Replacement Therapy in Children With Sinusoidal Obstruction Syndrome After Hematopoietic Cell Transplant: Outcome and Liberation.Pediatric blood & cancer · 2025Article
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Authors and funding
21 authors at 16 institutions in 4 countries.
Funding
Abstract
RATIONALE &
objectiveThere are limited studies describing the epidemiology and outcomes in children and young adults receiving continuous kidney replacement therapy (CKRT). We aimed to describe associations between patient characteristics, CKRT prescription, and survival. STUDY
designRetrospective multicenter cohort study. SETTING &
participants980 patients aged from birth to 25 years who received CKRT between 2015 and 2021 at 1 of 32 centers in 7 countries participating in WE-ROCK (Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Diseases). EXPOSURE: CKRT for acute kidney injury or volume overload. OUTCOMES: Death before intensive care unit (ICU) discharge. ANALYTICAL APPROACH: Descriptive statistics.
resultsMedian age was 8.8 years (IQR, 1.6-15.0), and median weight was 26.8 (IQR, 11.6-55.0) kg. CKRT was initiated a median of 2 (IQR, 1-6) days after ICU admission and lasted a median of 6 (IQR, 3-14) days. The most common CKRT modality was continuous venovenous hemodiafiltration. Citrate anticoagulation was used in 62%, and the internal jugular vein was the most common catheter placement location (66%). 629 participants (64.1%) survived at least until ICU discharge. CKRT dose, filter type, and anticoagulation were similar in those who did and did not survive to ICU discharge. There were apparent practice variations by institutional ICU size. LIMITATIONS: Retrospective design; limited representation from centers outside the United States.
conclusionsIn this study of children and young adults receiving CKRT, approximately two thirds survived at least until ICU discharge. Although variations in dialysis mode and dose, catheter size and location, and anticoagulation were observed, survival was not detected to be associated with these parameters. PLAIN-LANGUAGE SUMMARY: In this large contemporary epidemiological study of children and young adults receiving continuous kidney replacement therapy in the intensive care unit, we observed that two thirds of patients survived at least until ICU discharge. However, patients with comorbidities appeared to have worse outcomes. Compared with previously published reports on continuous kidney replacement therapy practice, we observed greater use of continuous venovenous hemodiafiltration with regional citrate anticoagulation.
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